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Urine as a Source of Liquid Biopsy for Cancer

SIMPLE SUMMARY: Tissue biopsy is essential for diagnosis and characterization of a tumor. Recently circulating tumor cells and other tumor-derived nucleic acid can be detected from blood, which is called liquid biopsy. Now this concept has been expanded to many other body fluids including urine. Uri...

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Autores principales: Oshi, Masanori, Murthy, Vijayashree, Takahashi, Hideo, Huyser, Michelle, Okano, Maiko, Tokumaru, Yoshihisa, Rashid, Omar M., Matsuyama, Ryusei, Endo, Itaru, Takabe, Kazuaki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199052/
https://www.ncbi.nlm.nih.gov/pubmed/34071230
http://dx.doi.org/10.3390/cancers13112652
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author Oshi, Masanori
Murthy, Vijayashree
Takahashi, Hideo
Huyser, Michelle
Okano, Maiko
Tokumaru, Yoshihisa
Rashid, Omar M.
Matsuyama, Ryusei
Endo, Itaru
Takabe, Kazuaki
author_facet Oshi, Masanori
Murthy, Vijayashree
Takahashi, Hideo
Huyser, Michelle
Okano, Maiko
Tokumaru, Yoshihisa
Rashid, Omar M.
Matsuyama, Ryusei
Endo, Itaru
Takabe, Kazuaki
author_sort Oshi, Masanori
collection PubMed
description SIMPLE SUMMARY: Tissue biopsy is essential for diagnosis and characterization of a tumor. Recently circulating tumor cells and other tumor-derived nucleic acid can be detected from blood, which is called liquid biopsy. Now this concept has been expanded to many other body fluids including urine. Urine is the least invasive method to obtain a liquid biopsy and can be done anywhere, which allows longitudinal repeated sampling. Here, we review the latest update on urine liquid biopsy in urological and non-urological cancers. ABSTRACT: Tissue biopsy is the gold standard for diagnosis and morphological and immunohistochemical analyses to characterize cancer. However, tissue biopsy usually requires an invasive procedure, and it can be challenging depending on the condition of the patient and the location of the tumor. Even liquid biopsy analysis of body fluids such as blood, saliva, gastric juice, sweat, tears and cerebrospinal fluid may require invasive procedures to obtain samples. Liquid biopsy can be applied to circulating tumor cells (CTCs) or nucleic acids (NAs) in blood. Recently, urine has gained popularity due to its less invasive sampling, ability to easily repeat samples, and ability to follow tumor evolution in real-time, making it a powerful tool for diagnosis and treatment monitoring in cancer patients. With the development and advancements in extraction methods of urinary substances, urinary NAs have been found to be closely related to carcinogenesis, metastasis, and therapeutic response, not only in urological cancers but also in non-urological cancers. This review mainly highlights the components of urine liquid biopsy and their utility and limitations in oncology, especially in non-urological cancers.
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spelling pubmed-81990522021-06-14 Urine as a Source of Liquid Biopsy for Cancer Oshi, Masanori Murthy, Vijayashree Takahashi, Hideo Huyser, Michelle Okano, Maiko Tokumaru, Yoshihisa Rashid, Omar M. Matsuyama, Ryusei Endo, Itaru Takabe, Kazuaki Cancers (Basel) Review SIMPLE SUMMARY: Tissue biopsy is essential for diagnosis and characterization of a tumor. Recently circulating tumor cells and other tumor-derived nucleic acid can be detected from blood, which is called liquid biopsy. Now this concept has been expanded to many other body fluids including urine. Urine is the least invasive method to obtain a liquid biopsy and can be done anywhere, which allows longitudinal repeated sampling. Here, we review the latest update on urine liquid biopsy in urological and non-urological cancers. ABSTRACT: Tissue biopsy is the gold standard for diagnosis and morphological and immunohistochemical analyses to characterize cancer. However, tissue biopsy usually requires an invasive procedure, and it can be challenging depending on the condition of the patient and the location of the tumor. Even liquid biopsy analysis of body fluids such as blood, saliva, gastric juice, sweat, tears and cerebrospinal fluid may require invasive procedures to obtain samples. Liquid biopsy can be applied to circulating tumor cells (CTCs) or nucleic acids (NAs) in blood. Recently, urine has gained popularity due to its less invasive sampling, ability to easily repeat samples, and ability to follow tumor evolution in real-time, making it a powerful tool for diagnosis and treatment monitoring in cancer patients. With the development and advancements in extraction methods of urinary substances, urinary NAs have been found to be closely related to carcinogenesis, metastasis, and therapeutic response, not only in urological cancers but also in non-urological cancers. This review mainly highlights the components of urine liquid biopsy and their utility and limitations in oncology, especially in non-urological cancers. MDPI 2021-05-28 /pmc/articles/PMC8199052/ /pubmed/34071230 http://dx.doi.org/10.3390/cancers13112652 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Oshi, Masanori
Murthy, Vijayashree
Takahashi, Hideo
Huyser, Michelle
Okano, Maiko
Tokumaru, Yoshihisa
Rashid, Omar M.
Matsuyama, Ryusei
Endo, Itaru
Takabe, Kazuaki
Urine as a Source of Liquid Biopsy for Cancer
title Urine as a Source of Liquid Biopsy for Cancer
title_full Urine as a Source of Liquid Biopsy for Cancer
title_fullStr Urine as a Source of Liquid Biopsy for Cancer
title_full_unstemmed Urine as a Source of Liquid Biopsy for Cancer
title_short Urine as a Source of Liquid Biopsy for Cancer
title_sort urine as a source of liquid biopsy for cancer
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199052/
https://www.ncbi.nlm.nih.gov/pubmed/34071230
http://dx.doi.org/10.3390/cancers13112652
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