The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL

During spermatogenesis, the Golgi apparatus serves important roles including the formation of the acrosome, which is a sperm-specific organelle essential for fertilization. We have previously demonstrated that D. melanogaster ATP-dependent Citrate Lyase (ATPCL) is required for spindle organization,...

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Detalles Bibliográficos
Autores principales: Morciano, Patrizia, Di Giorgio, Maria Laura, Tullo, Liliana, Cenci, Giovanni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199154/
https://www.ncbi.nlm.nih.gov/pubmed/34072207
http://dx.doi.org/10.3390/ijms22115745
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author Morciano, Patrizia
Di Giorgio, Maria Laura
Tullo, Liliana
Cenci, Giovanni
author_facet Morciano, Patrizia
Di Giorgio, Maria Laura
Tullo, Liliana
Cenci, Giovanni
author_sort Morciano, Patrizia
collection PubMed
description During spermatogenesis, the Golgi apparatus serves important roles including the formation of the acrosome, which is a sperm-specific organelle essential for fertilization. We have previously demonstrated that D. melanogaster ATP-dependent Citrate Lyase (ATPCL) is required for spindle organization, cytokinesis, and fusome assembly during male meiosis, mainly due to is activity on fatty acid biosynthesis. Here, we show that depletion of DmATPCL also affects the organization of acrosome and suggest a role for this enzyme in the assembly of Golgi-derived structures during Drosophila spermatogenesis.
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spelling pubmed-81991542021-06-14 The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL Morciano, Patrizia Di Giorgio, Maria Laura Tullo, Liliana Cenci, Giovanni Int J Mol Sci Communication During spermatogenesis, the Golgi apparatus serves important roles including the formation of the acrosome, which is a sperm-specific organelle essential for fertilization. We have previously demonstrated that D. melanogaster ATP-dependent Citrate Lyase (ATPCL) is required for spindle organization, cytokinesis, and fusome assembly during male meiosis, mainly due to is activity on fatty acid biosynthesis. Here, we show that depletion of DmATPCL also affects the organization of acrosome and suggest a role for this enzyme in the assembly of Golgi-derived structures during Drosophila spermatogenesis. MDPI 2021-05-27 /pmc/articles/PMC8199154/ /pubmed/34072207 http://dx.doi.org/10.3390/ijms22115745 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Communication
Morciano, Patrizia
Di Giorgio, Maria Laura
Tullo, Liliana
Cenci, Giovanni
The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
title The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
title_full The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
title_fullStr The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
title_full_unstemmed The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
title_short The Organization of the Golgi Structures during Drosophila Male Meiosis Requires the Citrate Lyase ATPCL
title_sort organization of the golgi structures during drosophila male meiosis requires the citrate lyase atpcl
topic Communication
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199154/
https://www.ncbi.nlm.nih.gov/pubmed/34072207
http://dx.doi.org/10.3390/ijms22115745
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