Combined Gemcitabine and Immune-Checkpoint Inhibition Conquers Anti-PD-L1 Resistance in Low-Immunogenic Mismatch Repair-Deficient Tumors

Tumors arising in the context of Lynch Syndrome or constitutional mismatch repair deficiency are hypermutated and have a good response towards immune-checkpoint inhibitors (ICIs), including α-PD-L1 antibodies. However, in most cases, resistance mechanisms evolve. To improve outcomes and prevent resi...

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Detalles Bibliográficos
Autores principales: Salewski, Inken, Henne, Julia, Engster, Leonie, Schneider, Bjoern, Lemcke, Heiko, Skorska, Anna, Berlin, Peggy, Henze, Larissa, Junghanss, Christian, Maletzki, Claudia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199186/
https://www.ncbi.nlm.nih.gov/pubmed/34206051
http://dx.doi.org/10.3390/ijms22115990

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