Structure-Based Design, Docking and Binding Free Energy Calculations of A366 Derivatives as Spindlin1 Inhibitors

The chromatin reader protein Spindlin1 plays an important role in epigenetic regulation, through which it has been linked to several types of malignant tumors. In the current work, we report on the development of novel analogs of the previously published lead inhibitor A366. In an effort to improve...

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Detalles Bibliográficos
Autores principales: Luise, Chiara, Robaa, Dina, Regenass, Pierre, Maurer, David, Ostrovskyi, Dmytro, Seifert, Ludwig, Bacher, Johannes, Burgahn, Teresa, Wagner, Tobias, Seitz, Johannes, Greschik, Holger, Park, Kwang-Su, Xiong, Yan, Jin, Jian, Schüle, Roland, Breit, Bernhard, Jung, Manfred, Sippl, Wolfgang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199216/
https://www.ncbi.nlm.nih.gov/pubmed/34072837
http://dx.doi.org/10.3390/ijms22115910

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