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Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans
This study examined the relationship between plasma amino acid (AA) concentrations, including branched-chain AAs, and brown adipose tissue density (BAT-d). One hundred and seventy-three subjects (69 men, 104 women) aged 22–68 years were recruited during the winter season. AAs were comprehensively qu...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199240/ https://www.ncbi.nlm.nih.gov/pubmed/34071816 http://dx.doi.org/10.3390/jcm10112339 |
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author | Kuroiwa, Miyuki Hamaoka-Fuse, Sayuri Sugimoto, Masahiro Kurosawa, Yuko Aita, Yasuko Tomita, Atsumi Anjo, Mikiko Tanaka, Riki Endo, Tasuki Kime, Ryotaro Hamaoka, Takafumi |
author_facet | Kuroiwa, Miyuki Hamaoka-Fuse, Sayuri Sugimoto, Masahiro Kurosawa, Yuko Aita, Yasuko Tomita, Atsumi Anjo, Mikiko Tanaka, Riki Endo, Tasuki Kime, Ryotaro Hamaoka, Takafumi |
author_sort | Kuroiwa, Miyuki |
collection | PubMed |
description | This study examined the relationship between plasma amino acid (AA) concentrations, including branched-chain AAs, and brown adipose tissue density (BAT-d). One hundred and seventy-three subjects (69 men, 104 women) aged 22–68 years were recruited during the winter season. AAs were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. The total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, was assessed using near-infrared time-resolved spectroscopy. Anthropometric parameters, including age, percentage of body fat, and visceral fat, were evaluated. Factors associated with higher (≥74 µM) or lower (<74 µM) [total-Hb]sup were investigated by multiple logistic regression models that included AA concentrations alone (model 1) or AA concentrations and anthropometric parameters (model 2) as independent variables. When adjusted for the false discovery rate, [total-Hb]sup was positively correlated with glycine and asparagine levels in men and with the serine level in both men and women and was negatively correlated with the branched-chain AA concentration in men. Models 1 and 2 correlated with higher or lower BAT-d for men (r = 0.73, p = 0.015) and women (r = 0.58, p = 0.079) and for men (r = 0.82, p = 0.0070) and women (r = 0.70, p = 0.020), respectively. A combination of anthropometric parameters and plasma AA concentrations could be a reliable biomarker for higher and lower BAT-d. |
format | Online Article Text |
id | pubmed-8199240 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81992402021-06-14 Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans Kuroiwa, Miyuki Hamaoka-Fuse, Sayuri Sugimoto, Masahiro Kurosawa, Yuko Aita, Yasuko Tomita, Atsumi Anjo, Mikiko Tanaka, Riki Endo, Tasuki Kime, Ryotaro Hamaoka, Takafumi J Clin Med Article This study examined the relationship between plasma amino acid (AA) concentrations, including branched-chain AAs, and brown adipose tissue density (BAT-d). One hundred and seventy-three subjects (69 men, 104 women) aged 22–68 years were recruited during the winter season. AAs were comprehensively quantified using liquid chromatography-time-of-flight-mass spectrometry. The total hemoglobin concentration in the supraclavicular region ([total-Hb]sup), an indicator of BAT-d, was assessed using near-infrared time-resolved spectroscopy. Anthropometric parameters, including age, percentage of body fat, and visceral fat, were evaluated. Factors associated with higher (≥74 µM) or lower (<74 µM) [total-Hb]sup were investigated by multiple logistic regression models that included AA concentrations alone (model 1) or AA concentrations and anthropometric parameters (model 2) as independent variables. When adjusted for the false discovery rate, [total-Hb]sup was positively correlated with glycine and asparagine levels in men and with the serine level in both men and women and was negatively correlated with the branched-chain AA concentration in men. Models 1 and 2 correlated with higher or lower BAT-d for men (r = 0.73, p = 0.015) and women (r = 0.58, p = 0.079) and for men (r = 0.82, p = 0.0070) and women (r = 0.70, p = 0.020), respectively. A combination of anthropometric parameters and plasma AA concentrations could be a reliable biomarker for higher and lower BAT-d. MDPI 2021-05-27 /pmc/articles/PMC8199240/ /pubmed/34071816 http://dx.doi.org/10.3390/jcm10112339 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Kuroiwa, Miyuki Hamaoka-Fuse, Sayuri Sugimoto, Masahiro Kurosawa, Yuko Aita, Yasuko Tomita, Atsumi Anjo, Mikiko Tanaka, Riki Endo, Tasuki Kime, Ryotaro Hamaoka, Takafumi Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans |
title | Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans |
title_full | Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans |
title_fullStr | Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans |
title_full_unstemmed | Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans |
title_short | Correlation of Plasma Amino Acid and Anthropometric Profiles with Brown Adipose Tissue Density in Humans |
title_sort | correlation of plasma amino acid and anthropometric profiles with brown adipose tissue density in humans |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199240/ https://www.ncbi.nlm.nih.gov/pubmed/34071816 http://dx.doi.org/10.3390/jcm10112339 |
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