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Recovery-Stress Response of Blood-Based Biomarkers

The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) afte...

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Autores principales: Hacker, Sebastian, Reichel, Thomas, Hecksteden, Anne, Weyh, Christopher, Gebhardt, Kristina, Pfeiffer, Mark, Ferrauti, Alexander, Kellmann, Michael, Meyer, Tim, Krüger, Karsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199256/
https://www.ncbi.nlm.nih.gov/pubmed/34072201
http://dx.doi.org/10.3390/ijerph18115776
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author Hacker, Sebastian
Reichel, Thomas
Hecksteden, Anne
Weyh, Christopher
Gebhardt, Kristina
Pfeiffer, Mark
Ferrauti, Alexander
Kellmann, Michael
Meyer, Tim
Krüger, Karsten
author_facet Hacker, Sebastian
Reichel, Thomas
Hecksteden, Anne
Weyh, Christopher
Gebhardt, Kristina
Pfeiffer, Mark
Ferrauti, Alexander
Kellmann, Michael
Meyer, Tim
Krüger, Karsten
author_sort Hacker, Sebastian
collection PubMed
description The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) after a minimum of one-day rest from exercise and another one in a ‘non-recovered’ state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentrations at NOR compared to REC time points. In badminton players, higher levels of CK and IL-17A at NOR were found. In contrast, a higher value for S100 calcium-binding protein A8 (S100A8) at REC was found in badminton players. Similar differences were found for BDNF in soccer players. Soccer players also showed increased levels of CK, and IL-6 at NOR compared to REC state. Several molecular markers were shown to be responsive to differing recovery-stress states, but their suitability as biomarkers in training must be further validated.
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spelling pubmed-81992562021-06-14 Recovery-Stress Response of Blood-Based Biomarkers Hacker, Sebastian Reichel, Thomas Hecksteden, Anne Weyh, Christopher Gebhardt, Kristina Pfeiffer, Mark Ferrauti, Alexander Kellmann, Michael Meyer, Tim Krüger, Karsten Int J Environ Res Public Health Article The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) after a minimum of one-day rest from exercise and another one in a ‘non-recovered’ state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentrations at NOR compared to REC time points. In badminton players, higher levels of CK and IL-17A at NOR were found. In contrast, a higher value for S100 calcium-binding protein A8 (S100A8) at REC was found in badminton players. Similar differences were found for BDNF in soccer players. Soccer players also showed increased levels of CK, and IL-6 at NOR compared to REC state. Several molecular markers were shown to be responsive to differing recovery-stress states, but their suitability as biomarkers in training must be further validated. MDPI 2021-05-27 /pmc/articles/PMC8199256/ /pubmed/34072201 http://dx.doi.org/10.3390/ijerph18115776 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hacker, Sebastian
Reichel, Thomas
Hecksteden, Anne
Weyh, Christopher
Gebhardt, Kristina
Pfeiffer, Mark
Ferrauti, Alexander
Kellmann, Michael
Meyer, Tim
Krüger, Karsten
Recovery-Stress Response of Blood-Based Biomarkers
title Recovery-Stress Response of Blood-Based Biomarkers
title_full Recovery-Stress Response of Blood-Based Biomarkers
title_fullStr Recovery-Stress Response of Blood-Based Biomarkers
title_full_unstemmed Recovery-Stress Response of Blood-Based Biomarkers
title_short Recovery-Stress Response of Blood-Based Biomarkers
title_sort recovery-stress response of blood-based biomarkers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199256/
https://www.ncbi.nlm.nih.gov/pubmed/34072201
http://dx.doi.org/10.3390/ijerph18115776
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