Cargando…
Recovery-Stress Response of Blood-Based Biomarkers
The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) afte...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199256/ https://www.ncbi.nlm.nih.gov/pubmed/34072201 http://dx.doi.org/10.3390/ijerph18115776 |
_version_ | 1783707333794201600 |
---|---|
author | Hacker, Sebastian Reichel, Thomas Hecksteden, Anne Weyh, Christopher Gebhardt, Kristina Pfeiffer, Mark Ferrauti, Alexander Kellmann, Michael Meyer, Tim Krüger, Karsten |
author_facet | Hacker, Sebastian Reichel, Thomas Hecksteden, Anne Weyh, Christopher Gebhardt, Kristina Pfeiffer, Mark Ferrauti, Alexander Kellmann, Michael Meyer, Tim Krüger, Karsten |
author_sort | Hacker, Sebastian |
collection | PubMed |
description | The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) after a minimum of one-day rest from exercise and another one in a ‘non-recovered’ state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentrations at NOR compared to REC time points. In badminton players, higher levels of CK and IL-17A at NOR were found. In contrast, a higher value for S100 calcium-binding protein A8 (S100A8) at REC was found in badminton players. Similar differences were found for BDNF in soccer players. Soccer players also showed increased levels of CK, and IL-6 at NOR compared to REC state. Several molecular markers were shown to be responsive to differing recovery-stress states, but their suitability as biomarkers in training must be further validated. |
format | Online Article Text |
id | pubmed-8199256 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81992562021-06-14 Recovery-Stress Response of Blood-Based Biomarkers Hacker, Sebastian Reichel, Thomas Hecksteden, Anne Weyh, Christopher Gebhardt, Kristina Pfeiffer, Mark Ferrauti, Alexander Kellmann, Michael Meyer, Tim Krüger, Karsten Int J Environ Res Public Health Article The purpose of this study was to investigate blood-based biomarkers and their regulation with regard to different recovery-stress states. A total of 35 male elite athletes (13 badminton, 22 soccer players) were recruited, and two venous blood samples were taken: one in a ‘recovered’ state (REC) after a minimum of one-day rest from exercise and another one in a ‘non-recovered’ state (NOR) after a habitual loading microcycle. Overall, 23 blood-based biomarkers of different physiologic domains, which address inflammation, muscle damage, and tissue repair, were analyzed by Luminex assays. Across all athletes, only creatine kinase (CK), interleukin (IL-) 6, and IL-17A showed higher concentrations at NOR compared to REC time points. In badminton players, higher levels of CK and IL-17A at NOR were found. In contrast, a higher value for S100 calcium-binding protein A8 (S100A8) at REC was found in badminton players. Similar differences were found for BDNF in soccer players. Soccer players also showed increased levels of CK, and IL-6 at NOR compared to REC state. Several molecular markers were shown to be responsive to differing recovery-stress states, but their suitability as biomarkers in training must be further validated. MDPI 2021-05-27 /pmc/articles/PMC8199256/ /pubmed/34072201 http://dx.doi.org/10.3390/ijerph18115776 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Hacker, Sebastian Reichel, Thomas Hecksteden, Anne Weyh, Christopher Gebhardt, Kristina Pfeiffer, Mark Ferrauti, Alexander Kellmann, Michael Meyer, Tim Krüger, Karsten Recovery-Stress Response of Blood-Based Biomarkers |
title | Recovery-Stress Response of Blood-Based Biomarkers |
title_full | Recovery-Stress Response of Blood-Based Biomarkers |
title_fullStr | Recovery-Stress Response of Blood-Based Biomarkers |
title_full_unstemmed | Recovery-Stress Response of Blood-Based Biomarkers |
title_short | Recovery-Stress Response of Blood-Based Biomarkers |
title_sort | recovery-stress response of blood-based biomarkers |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199256/ https://www.ncbi.nlm.nih.gov/pubmed/34072201 http://dx.doi.org/10.3390/ijerph18115776 |
work_keys_str_mv | AT hackersebastian recoverystressresponseofbloodbasedbiomarkers AT reichelthomas recoverystressresponseofbloodbasedbiomarkers AT heckstedenanne recoverystressresponseofbloodbasedbiomarkers AT weyhchristopher recoverystressresponseofbloodbasedbiomarkers AT gebhardtkristina recoverystressresponseofbloodbasedbiomarkers AT pfeiffermark recoverystressresponseofbloodbasedbiomarkers AT ferrautialexander recoverystressresponseofbloodbasedbiomarkers AT kellmannmichael recoverystressresponseofbloodbasedbiomarkers AT meyertim recoverystressresponseofbloodbasedbiomarkers AT krugerkarsten recoverystressresponseofbloodbasedbiomarkers |