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Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS

Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical...

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Autores principales: Daher, Ayham, Cornelissen, Christian, Hartmann, Niels-Ulrik, Balfanz, Paul, Müller, Annegret, Bergs, Ingmar, Aetou, Maria, Marx, Nikolaus, Marx, Gernot, Simon, Tim-Philipp, Müller-Wieland, Dirk, Hartmann, Bojan, Kersten, Alexander, Müller, Tobias, Dreher, Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199360/
https://www.ncbi.nlm.nih.gov/pubmed/34072557
http://dx.doi.org/10.3390/ijerph18115861
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author Daher, Ayham
Cornelissen, Christian
Hartmann, Niels-Ulrik
Balfanz, Paul
Müller, Annegret
Bergs, Ingmar
Aetou, Maria
Marx, Nikolaus
Marx, Gernot
Simon, Tim-Philipp
Müller-Wieland, Dirk
Hartmann, Bojan
Kersten, Alexander
Müller, Tobias
Dreher, Michael
author_facet Daher, Ayham
Cornelissen, Christian
Hartmann, Niels-Ulrik
Balfanz, Paul
Müller, Annegret
Bergs, Ingmar
Aetou, Maria
Marx, Nikolaus
Marx, Gernot
Simon, Tim-Philipp
Müller-Wieland, Dirk
Hartmann, Bojan
Kersten, Alexander
Müller, Tobias
Dreher, Michael
author_sort Daher, Ayham
collection PubMed
description Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical ventilation (IMV) were followed six months after discharge. Pulmonary function tests (PFTs), 6-min walk test (6MWT) and echocardiography were performed. Quality of life (QoL), depression and anxiety were assessed using validated questionnaires. Patients were compared based on respiratory mechanics and CT-phenotype during intensive care unit (ICU) stay. Eighteen patients were included (61 ± 7 years; ICU-stay: 34 ± 16 days; IMV: 30 ± 15 days). At follow-up (197 ± 15 days after discharge), PFTs did not reveal significant limitations (VC: 92 ± 16%; FEV1: 92 ± 20%; DLco/VA: 81 ± 16%). Cardiac systolic function was normal in all patients, but 50% of them had diastolic dysfunction. 6MWT was under the lower limit of normal in only two patients. Eight patients (44%) reported tiredness, six (33%) suffered from fatigue and one patient (6%) had depression and anxiety. Surprisingly, patients with worse respiratory mechanics during IMV reported fewer symptoms and less exertional dyspnea at follow-up. In conclusion, patients with COVID-19-ARDS have the possibility to fully recover regarding pulmonary function and exercise capacity, which seems to be independent of disease severity during ICU stay.
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spelling pubmed-81993602021-06-14 Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS Daher, Ayham Cornelissen, Christian Hartmann, Niels-Ulrik Balfanz, Paul Müller, Annegret Bergs, Ingmar Aetou, Maria Marx, Nikolaus Marx, Gernot Simon, Tim-Philipp Müller-Wieland, Dirk Hartmann, Bojan Kersten, Alexander Müller, Tobias Dreher, Michael Int J Environ Res Public Health Article Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical ventilation (IMV) were followed six months after discharge. Pulmonary function tests (PFTs), 6-min walk test (6MWT) and echocardiography were performed. Quality of life (QoL), depression and anxiety were assessed using validated questionnaires. Patients were compared based on respiratory mechanics and CT-phenotype during intensive care unit (ICU) stay. Eighteen patients were included (61 ± 7 years; ICU-stay: 34 ± 16 days; IMV: 30 ± 15 days). At follow-up (197 ± 15 days after discharge), PFTs did not reveal significant limitations (VC: 92 ± 16%; FEV1: 92 ± 20%; DLco/VA: 81 ± 16%). Cardiac systolic function was normal in all patients, but 50% of them had diastolic dysfunction. 6MWT was under the lower limit of normal in only two patients. Eight patients (44%) reported tiredness, six (33%) suffered from fatigue and one patient (6%) had depression and anxiety. Surprisingly, patients with worse respiratory mechanics during IMV reported fewer symptoms and less exertional dyspnea at follow-up. In conclusion, patients with COVID-19-ARDS have the possibility to fully recover regarding pulmonary function and exercise capacity, which seems to be independent of disease severity during ICU stay. MDPI 2021-05-29 /pmc/articles/PMC8199360/ /pubmed/34072557 http://dx.doi.org/10.3390/ijerph18115861 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Daher, Ayham
Cornelissen, Christian
Hartmann, Niels-Ulrik
Balfanz, Paul
Müller, Annegret
Bergs, Ingmar
Aetou, Maria
Marx, Nikolaus
Marx, Gernot
Simon, Tim-Philipp
Müller-Wieland, Dirk
Hartmann, Bojan
Kersten, Alexander
Müller, Tobias
Dreher, Michael
Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
title Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
title_full Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
title_fullStr Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
title_full_unstemmed Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
title_short Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
title_sort six months follow-up of patients with invasive mechanical ventilation due to covid-19 related ards
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199360/
https://www.ncbi.nlm.nih.gov/pubmed/34072557
http://dx.doi.org/10.3390/ijerph18115861
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