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Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS
Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199360/ https://www.ncbi.nlm.nih.gov/pubmed/34072557 http://dx.doi.org/10.3390/ijerph18115861 |
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author | Daher, Ayham Cornelissen, Christian Hartmann, Niels-Ulrik Balfanz, Paul Müller, Annegret Bergs, Ingmar Aetou, Maria Marx, Nikolaus Marx, Gernot Simon, Tim-Philipp Müller-Wieland, Dirk Hartmann, Bojan Kersten, Alexander Müller, Tobias Dreher, Michael |
author_facet | Daher, Ayham Cornelissen, Christian Hartmann, Niels-Ulrik Balfanz, Paul Müller, Annegret Bergs, Ingmar Aetou, Maria Marx, Nikolaus Marx, Gernot Simon, Tim-Philipp Müller-Wieland, Dirk Hartmann, Bojan Kersten, Alexander Müller, Tobias Dreher, Michael |
author_sort | Daher, Ayham |
collection | PubMed |
description | Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical ventilation (IMV) were followed six months after discharge. Pulmonary function tests (PFTs), 6-min walk test (6MWT) and echocardiography were performed. Quality of life (QoL), depression and anxiety were assessed using validated questionnaires. Patients were compared based on respiratory mechanics and CT-phenotype during intensive care unit (ICU) stay. Eighteen patients were included (61 ± 7 years; ICU-stay: 34 ± 16 days; IMV: 30 ± 15 days). At follow-up (197 ± 15 days after discharge), PFTs did not reveal significant limitations (VC: 92 ± 16%; FEV1: 92 ± 20%; DLco/VA: 81 ± 16%). Cardiac systolic function was normal in all patients, but 50% of them had diastolic dysfunction. 6MWT was under the lower limit of normal in only two patients. Eight patients (44%) reported tiredness, six (33%) suffered from fatigue and one patient (6%) had depression and anxiety. Surprisingly, patients with worse respiratory mechanics during IMV reported fewer symptoms and less exertional dyspnea at follow-up. In conclusion, patients with COVID-19-ARDS have the possibility to fully recover regarding pulmonary function and exercise capacity, which seems to be independent of disease severity during ICU stay. |
format | Online Article Text |
id | pubmed-8199360 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81993602021-06-14 Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS Daher, Ayham Cornelissen, Christian Hartmann, Niels-Ulrik Balfanz, Paul Müller, Annegret Bergs, Ingmar Aetou, Maria Marx, Nikolaus Marx, Gernot Simon, Tim-Philipp Müller-Wieland, Dirk Hartmann, Bojan Kersten, Alexander Müller, Tobias Dreher, Michael Int J Environ Res Public Health Article Although patients who recovered from acute coronavirus disease 2019 (COVID-19) may have prolonged disabilities, follow-up data of those who have survived COVID-19 related acute respiratory distress syndrome (ARDS) is still very scarce. Therefore, COVID-19-ARDS survivors requiring invasive mechanical ventilation (IMV) were followed six months after discharge. Pulmonary function tests (PFTs), 6-min walk test (6MWT) and echocardiography were performed. Quality of life (QoL), depression and anxiety were assessed using validated questionnaires. Patients were compared based on respiratory mechanics and CT-phenotype during intensive care unit (ICU) stay. Eighteen patients were included (61 ± 7 years; ICU-stay: 34 ± 16 days; IMV: 30 ± 15 days). At follow-up (197 ± 15 days after discharge), PFTs did not reveal significant limitations (VC: 92 ± 16%; FEV1: 92 ± 20%; DLco/VA: 81 ± 16%). Cardiac systolic function was normal in all patients, but 50% of them had diastolic dysfunction. 6MWT was under the lower limit of normal in only two patients. Eight patients (44%) reported tiredness, six (33%) suffered from fatigue and one patient (6%) had depression and anxiety. Surprisingly, patients with worse respiratory mechanics during IMV reported fewer symptoms and less exertional dyspnea at follow-up. In conclusion, patients with COVID-19-ARDS have the possibility to fully recover regarding pulmonary function and exercise capacity, which seems to be independent of disease severity during ICU stay. MDPI 2021-05-29 /pmc/articles/PMC8199360/ /pubmed/34072557 http://dx.doi.org/10.3390/ijerph18115861 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Daher, Ayham Cornelissen, Christian Hartmann, Niels-Ulrik Balfanz, Paul Müller, Annegret Bergs, Ingmar Aetou, Maria Marx, Nikolaus Marx, Gernot Simon, Tim-Philipp Müller-Wieland, Dirk Hartmann, Bojan Kersten, Alexander Müller, Tobias Dreher, Michael Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS |
title | Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS |
title_full | Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS |
title_fullStr | Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS |
title_full_unstemmed | Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS |
title_short | Six Months Follow-Up of Patients with Invasive Mechanical Ventilation Due to COVID-19 Related ARDS |
title_sort | six months follow-up of patients with invasive mechanical ventilation due to covid-19 related ards |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199360/ https://www.ncbi.nlm.nih.gov/pubmed/34072557 http://dx.doi.org/10.3390/ijerph18115861 |
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