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Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway

BACKGROUND: The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. METHODS: Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laborat...

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Autores principales: Eldholm, Vegard, Rønning, Janne O., Mengshoel, Anne Torunn, Arnesen, Trude
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199368/
https://www.ncbi.nlm.nih.gov/pubmed/34118874
http://dx.doi.org/10.1186/s12879-021-06269-3
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author Eldholm, Vegard
Rønning, Janne O.
Mengshoel, Anne Torunn
Arnesen, Trude
author_facet Eldholm, Vegard
Rønning, Janne O.
Mengshoel, Anne Torunn
Arnesen, Trude
author_sort Eldholm, Vegard
collection PubMed
description BACKGROUND: The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. METHODS: Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laboratory for Mycobacteria (NRL) and identified as MAF in Norway, in the period 2010–2020. Phylogenetic analyses were performed. RESULTS: The analyses indicated several imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis. CONCLUSIONS: Most MAF cases in Norway are the result of import, but transmission is occurring within Norway.
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spelling pubmed-81993682021-06-15 Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway Eldholm, Vegard Rønning, Janne O. Mengshoel, Anne Torunn Arnesen, Trude BMC Infect Dis Research Article BACKGROUND: The aim of the current study was to improve our understanding of the origins and transmission of Mycobacterium africanum (MAF) in Norway. METHODS: Whole-genome sequences (WGS) were generated for all (n = 29) available clinical isolates received at the Norwegian National Reference Laboratory for Mycobacteria (NRL) and identified as MAF in Norway, in the period 2010–2020. Phylogenetic analyses were performed. RESULTS: The analyses indicated several imports of MAF lineage 6 from both East and West African countries, whereas MAF lineage 5 was restricted to patients with West African connections. We also find evidence for transmission of MAF in Norway. Finally, our analyses revealed that a group of isolates from patients originating in South Asia, identified as MAF by means of a commercial line-probe assay, in fact belonged to Mycobacterium orygis. CONCLUSIONS: Most MAF cases in Norway are the result of import, but transmission is occurring within Norway. BioMed Central 2021-06-12 /pmc/articles/PMC8199368/ /pubmed/34118874 http://dx.doi.org/10.1186/s12879-021-06269-3 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Research Article
Eldholm, Vegard
Rønning, Janne O.
Mengshoel, Anne Torunn
Arnesen, Trude
Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
title Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
title_full Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
title_fullStr Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
title_full_unstemmed Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
title_short Import and transmission of Mycobacterium orygis and Mycobacterium africanum, Norway
title_sort import and transmission of mycobacterium orygis and mycobacterium africanum, norway
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199368/
https://www.ncbi.nlm.nih.gov/pubmed/34118874
http://dx.doi.org/10.1186/s12879-021-06269-3
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