Induced Mitochondrial Alteration and DNA Damage via IFNGR-JAK2-STAT1-PARP1 Pathway Facilitates Viral Hepatitis Associated Hepatocellular Carcinoma Aggressiveness and Stemness

SIMPLE SUMMARY: Hepatitis virus is a major risk factor for liver cancer. We analyzed possible synergism between momelotinib and sorafenib in hepatitis virus-associated liver cancer. The combined effect of momelotinib and sorafenib both at in vitro and in vivo synergistically sup-presses the prolifer...

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Detalles Bibliográficos
Autores principales: Cherng, Yih-Giun, Chu, Yi Cheng, Yadav, Vijesh Kumar, Huang, Ting-Yi, Hsieh, Ming-Shou, Lee, Kwai-Fong, Lee, Wei-Hwa, Yeh, Chi-Tai, Ong, Jiann Ruey
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199505/
https://www.ncbi.nlm.nih.gov/pubmed/34199353
http://dx.doi.org/10.3390/cancers13112755

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199505/
https://www.ncbi.nlm.nih.gov/pubmed/34199353
http://dx.doi.org/10.3390/cancers13112755

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