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Gender-Dependent Phenotype in Polycystic Kidney Disease Is Determined by Differential Intracellular Ca(2+) Signals

Autosomal dominant polycystic kidney disease (ADPKD) is caused by loss of function of PKD1 (polycystin 1) or PKD2 (polycystin 2). The Ca(2+)-activated Cl(−) channel TMEM16A has a central role in ADPKD. Expression and function of TMEM16A is upregulated in ADPKD which causes enhanced intracellular Ca(...

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Detalles Bibliográficos
Autores principales:	Talbi, Khaoula, Cabrita, Inês, Schreiber, Rainer, Kunzelmann, Karl
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199720/ https://www.ncbi.nlm.nih.gov/pubmed/34199520 http://dx.doi.org/10.3390/ijms22116019

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