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Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences

Alginate (ALG), a polysaccharide derived from brown seaweed, has been extensively investigated as a biomaterial not only in tissue engineering but also for numerous biomedical sciences owing to its wide availability, good compatibility, weak cytotoxicity, low cost, and ease of gelation. Nevertheless...

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Detalles Bibliográficos
Autores principales: Hu, Tingyu, Lo, Amy C. Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199729/
https://www.ncbi.nlm.nih.gov/pubmed/34199641
http://dx.doi.org/10.3390/polym13111852
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author Hu, Tingyu
Lo, Amy C. Y.
author_facet Hu, Tingyu
Lo, Amy C. Y.
author_sort Hu, Tingyu
collection PubMed
description Alginate (ALG), a polysaccharide derived from brown seaweed, has been extensively investigated as a biomaterial not only in tissue engineering but also for numerous biomedical sciences owing to its wide availability, good compatibility, weak cytotoxicity, low cost, and ease of gelation. Nevertheless, alginate lacks cell-binding sites, limiting long-term cell survival and viability in 3D culture. Collagen (Col), a major component protein found in the extracellular matrix (ECM), exhibits excellent biocompatibility and weak immunogenicity. Furthermore, collagen contains cell-binding motifs, which facilitate cell attachment, interaction, and spreading, consequently maintaining cell viability and promoting cell proliferation. Recently, there has been a growing body of investigations into collagen-based hydrogel trying to overcome the poor mechanical properties of collagen. In particular, collagen–alginate composite (CAC) hydrogel has attracted much attention due to its excellent biocompatibility, gelling under mild conditions, low cytotoxicity, controllable mechanic properties, wider availability as well as ease of incorporation of other biomaterials and bioactive agents. This review aims to provide an overview of the properties of alginate and collagen. Moreover, the application of CAC hydrogel in tissue engineering and biomedical sciences is also discussed.
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spelling pubmed-81997292021-06-14 Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences Hu, Tingyu Lo, Amy C. Y. Polymers (Basel) Review Alginate (ALG), a polysaccharide derived from brown seaweed, has been extensively investigated as a biomaterial not only in tissue engineering but also for numerous biomedical sciences owing to its wide availability, good compatibility, weak cytotoxicity, low cost, and ease of gelation. Nevertheless, alginate lacks cell-binding sites, limiting long-term cell survival and viability in 3D culture. Collagen (Col), a major component protein found in the extracellular matrix (ECM), exhibits excellent biocompatibility and weak immunogenicity. Furthermore, collagen contains cell-binding motifs, which facilitate cell attachment, interaction, and spreading, consequently maintaining cell viability and promoting cell proliferation. Recently, there has been a growing body of investigations into collagen-based hydrogel trying to overcome the poor mechanical properties of collagen. In particular, collagen–alginate composite (CAC) hydrogel has attracted much attention due to its excellent biocompatibility, gelling under mild conditions, low cytotoxicity, controllable mechanic properties, wider availability as well as ease of incorporation of other biomaterials and bioactive agents. This review aims to provide an overview of the properties of alginate and collagen. Moreover, the application of CAC hydrogel in tissue engineering and biomedical sciences is also discussed. MDPI 2021-06-02 /pmc/articles/PMC8199729/ /pubmed/34199641 http://dx.doi.org/10.3390/polym13111852 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hu, Tingyu
Lo, Amy C. Y.
Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
title Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
title_full Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
title_fullStr Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
title_full_unstemmed Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
title_short Collagen–Alginate Composite Hydrogel: Application in Tissue Engineering and Biomedical Sciences
title_sort collagen–alginate composite hydrogel: application in tissue engineering and biomedical sciences
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199729/
https://www.ncbi.nlm.nih.gov/pubmed/34199641
http://dx.doi.org/10.3390/polym13111852
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