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Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study

The epidemiological and clinical characteristics, treatments, and outcomes of patients with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately evaluated in Japan. We analyzed the registry data of 205 patients with COVID-19 admitted to the I...

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Autores principales: Zha, Ling, Sobue, Tomotaka, Takeuchi, Taro, Tanaka, Kenta, Katayama, Yusuke, Komukai, Sho, Hirayama, Atsushi, Shimazu, Takeshi, Kitamura, Tetsuhisa
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199743/
https://www.ncbi.nlm.nih.gov/pubmed/34204934
http://dx.doi.org/10.3390/jcm10112477
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author Zha, Ling
Sobue, Tomotaka
Takeuchi, Taro
Tanaka, Kenta
Katayama, Yusuke
Komukai, Sho
Hirayama, Atsushi
Shimazu, Takeshi
Kitamura, Tetsuhisa
author_facet Zha, Ling
Sobue, Tomotaka
Takeuchi, Taro
Tanaka, Kenta
Katayama, Yusuke
Komukai, Sho
Hirayama, Atsushi
Shimazu, Takeshi
Kitamura, Tetsuhisa
author_sort Zha, Ling
collection PubMed
description The epidemiological and clinical characteristics, treatments, and outcomes of patients with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately evaluated in Japan. We analyzed the registry data of 205 patients with COVID-19 admitted to the ICU between February and November 2020, in Osaka Prefecture, Japan. A Cox proportional hazards model was used to assess the association between epidemiological factors and mortality among ICU patients. Of the 205 ICU patients, 161 (78.5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had comorbidities. The most common symptoms at diagnosis were mild (n = 131, 63.9%). A total of 187 patients (91.2%) received mechanical ventilation, and 32 patients (15.6%) required extracorporeal membrane oxygenation. Patients were followed up for a median of 25 days after ICU admission. A total of 147 patients (71.7%) were alive at discharge, and 58 patients (28.3%) died. The hazard ratio for mortality among patients aged >80 years was 6.02 (95% confidence interval: 2.10−17.25) in the multivariable model, which was higher than that among those aged ≤59 years. These results are useful for recognizing the clinical course of this infection in ICU patients.
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spelling pubmed-81997432021-06-14 Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study Zha, Ling Sobue, Tomotaka Takeuchi, Taro Tanaka, Kenta Katayama, Yusuke Komukai, Sho Hirayama, Atsushi Shimazu, Takeshi Kitamura, Tetsuhisa J Clin Med Article The epidemiological and clinical characteristics, treatments, and outcomes of patients with coronavirus disease 2019 (COVID-19) who are admitted to the intensive care unit (ICU) have not been adequately evaluated in Japan. We analyzed the registry data of 205 patients with COVID-19 admitted to the ICU between February and November 2020, in Osaka Prefecture, Japan. A Cox proportional hazards model was used to assess the association between epidemiological factors and mortality among ICU patients. Of the 205 ICU patients, 161 (78.5%) were men and 149 (72.7%) were older than 60 years. A total of 117 patients (57.1%) had comorbidities. The most common symptoms at diagnosis were mild (n = 131, 63.9%). A total of 187 patients (91.2%) received mechanical ventilation, and 32 patients (15.6%) required extracorporeal membrane oxygenation. Patients were followed up for a median of 25 days after ICU admission. A total of 147 patients (71.7%) were alive at discharge, and 58 patients (28.3%) died. The hazard ratio for mortality among patients aged >80 years was 6.02 (95% confidence interval: 2.10−17.25) in the multivariable model, which was higher than that among those aged ≤59 years. These results are useful for recognizing the clinical course of this infection in ICU patients. MDPI 2021-06-03 /pmc/articles/PMC8199743/ /pubmed/34204934 http://dx.doi.org/10.3390/jcm10112477 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Zha, Ling
Sobue, Tomotaka
Takeuchi, Taro
Tanaka, Kenta
Katayama, Yusuke
Komukai, Sho
Hirayama, Atsushi
Shimazu, Takeshi
Kitamura, Tetsuhisa
Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study
title Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study
title_full Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study
title_fullStr Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study
title_full_unstemmed Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study
title_short Characteristics and Survival of Intensive Care Unit Patients with Coronavirus Disease in Osaka, Japan: A Retrospective Observational Study
title_sort characteristics and survival of intensive care unit patients with coronavirus disease in osaka, japan: a retrospective observational study
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199743/
https://www.ncbi.nlm.nih.gov/pubmed/34204934
http://dx.doi.org/10.3390/jcm10112477
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