Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides

Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interes...

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Detalles Bibliográficos
Autores principales: Scarel, Marco, Marchesan, Silvia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199760/
https://www.ncbi.nlm.nih.gov/pubmed/34204905
http://dx.doi.org/10.3390/molecules26113376
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author Scarel, Marco
Marchesan, Silvia
author_facet Scarel, Marco
Marchesan, Silvia
author_sort Scarel, Marco
collection PubMed
description Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications.
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spelling pubmed-81997602021-06-14 Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides Scarel, Marco Marchesan, Silvia Molecules Review Cyclodipeptides (CDPs) or 2,5-diketopiperazines (DKPs) can exert a variety of biological activities and display pronounced resistance against enzymatic hydrolysis as well as a propensity towards self-assembly into gels, relative to the linear-dipeptide counterparts. They have attracted great interest in a variety of fields spanning from functional materials to drug discovery. This concise review will analyze the latest advancements in their synthesis, self-assembly into gels, and their more innovative applications. MDPI 2021-06-03 /pmc/articles/PMC8199760/ /pubmed/34204905 http://dx.doi.org/10.3390/molecules26113376 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Scarel, Marco
Marchesan, Silvia
Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_full Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_fullStr Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_full_unstemmed Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_short Diketopiperazine Gels: New Horizons from the Self-Assembly of Cyclic Dipeptides
title_sort diketopiperazine gels: new horizons from the self-assembly of cyclic dipeptides
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199760/
https://www.ncbi.nlm.nih.gov/pubmed/34204905
http://dx.doi.org/10.3390/molecules26113376
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