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CuI-Catalyzed Coupling Reactions of 4-Iodopyrazoles and Alcohols: Application toward Withasomnine and Homologs
The direct 4-alkoxylation of 4-iodo-1H-pyrazoles with alcohols was achieved by a CuI-catalyzed coupling protocol. The optimal reaction conditions employed excess alcohol and potassium t-butoxide (2 equiv) in the presence of CuI (20 mol%) and 3,4,7,8-tetramethyl-1,10-phenanthroline (20 mol%) at 130 °...
Autores principales: | Usami, Yoshihide, Kubo, Yumika, Takagaki, Toshiki, Kuroiwa, Nao, Ono, Jun, Nishikawa, Kohei, Nakamizu, Ayaka, Tatsui, Yuya, Harusawa, Shinya, Hayama, Noboru, Yoneyama, Hiroki |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199780/ https://www.ncbi.nlm.nih.gov/pubmed/34199652 http://dx.doi.org/10.3390/molecules26113370 |
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