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The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review
Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspond...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199880/ https://www.ncbi.nlm.nih.gov/pubmed/34204976 http://dx.doi.org/10.3390/ma14113045 |
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author | Alberti, Alice Francetti, Luca Taschieri, Silvio Corbella, Stefano |
author_facet | Alberti, Alice Francetti, Luca Taschieri, Silvio Corbella, Stefano |
author_sort | Alberti, Alice |
collection | PubMed |
description | Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy. |
format | Online Article Text |
id | pubmed-8199880 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-81998802021-06-14 The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review Alberti, Alice Francetti, Luca Taschieri, Silvio Corbella, Stefano Materials (Basel) Review Enamel matrix derivative (EMD) has been successfully used for periodontal regeneration in intrabony defects. Recently, its use for peri-implant bone regeneration has also been hypothesized. The aim of this paper is to review preclinical and clinical studies investigating the use of EMD in correspondence with titanium implants, alone or as an adjunct to other biomaterials. Clinical trials and case series with more than five cases were included. Seven in vitro studies evaluated the effect of EMD, placed on titanium surfaces: An increase in proliferation and viability of osteoblasts was observed in all but two studies. An increase in TGF-β1 and osteocalcin production, alkaline phosphatase activity, and angiogenesis was also reported. Nine animal studies investigated the use of EMD at implant placement or for bone regeneration of peri-implant bone defects, and some of them reported a significant increase in bone formation or bone-to-implant contact. In four of eleven clinical trials on humans, EMD was successfully used at implant placement. The other seven evaluated the use of EMD in protocols for the treatment of peri-implantitis. In conclusion, the results of EMD seem promising, but further randomized clinical trials are needed to evaluate its efficacy. MDPI 2021-06-03 /pmc/articles/PMC8199880/ /pubmed/34204976 http://dx.doi.org/10.3390/ma14113045 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Alberti, Alice Francetti, Luca Taschieri, Silvio Corbella, Stefano The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review |
title | The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review |
title_full | The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review |
title_fullStr | The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review |
title_full_unstemmed | The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review |
title_short | The Applications of Enamel Matrix Derivative in Implant Dentistry: A Narrative Review |
title_sort | applications of enamel matrix derivative in implant dentistry: a narrative review |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8199880/ https://www.ncbi.nlm.nih.gov/pubmed/34204976 http://dx.doi.org/10.3390/ma14113045 |
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