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Use of high-content imaging to quantify transduction of AAV-PHP viruses in the brain following systemic delivery

The engineering of the AAV-PHP capsids was an important development for CNS research and the modulation of gene expression in the brain. They cross the blood brain barrier and transduce brain cells after intravenous systemic delivery, a property dependent on the genotype of Ly6a, the AAV-PHP capsid...

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Detalles Bibliográficos
Autores principales:	Smith, Edward J, Farshim, Pamela P, Flomen, Rachel, Jones, Samuel T, McAteer, Sean J, Deverman, Benjamin E, Gradinaru, Viviana, Bates, Gillian P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2021
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200048/ https://www.ncbi.nlm.nih.gov/pubmed/34131644 http://dx.doi.org/10.1093/braincomms/fcab105

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