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Memory Generation and Re-Activation in Food Allergy
Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG(+) memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan o...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200165/ https://www.ncbi.nlm.nih.gov/pubmed/34136419 http://dx.doi.org/10.2147/ITT.S284823 |
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author | Koenig, Joshua F E Bruton, Kelly Phelps, Allyssa Grydziuszko, Emily Jiménez-Saiz, Rodrigo Jordana, Manel |
author_facet | Koenig, Joshua F E Bruton, Kelly Phelps, Allyssa Grydziuszko, Emily Jiménez-Saiz, Rodrigo Jordana, Manel |
author_sort | Koenig, Joshua F E |
collection | PubMed |
description | Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG(+) memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, although how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation, specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy. |
format | Online Article Text |
id | pubmed-8200165 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Dove |
record_format | MEDLINE/PubMed |
spelling | pubmed-82001652021-06-15 Memory Generation and Re-Activation in Food Allergy Koenig, Joshua F E Bruton, Kelly Phelps, Allyssa Grydziuszko, Emily Jiménez-Saiz, Rodrigo Jordana, Manel Immunotargets Ther Review Recent evidence has highlighted the critical role of memory cells in maintaining lifelong food allergies, thereby identifying these cells as therapeutic targets. IgG(+) memory B cells replenish pools of IgE-secreting cells upon allergen exposure, which contract thereafter due to the short lifespan of tightly regulated IgE-expressing cells. Advances in the detection and highly dimensional analysis of allergen-specific B and T cells from allergic patients have provided insight on their phenotype and function. The newly identified Th2A and Tfh13 populations represent a leap in our understanding of allergen-specific T cell phenotypes, although how these populations contribute to IgE memory responses remains poorly understood. Within, we discuss the mechanisms by which memory B and T cells are activated, integrating knowledge from human systems and fundamental research. We then focus on memory reactivation, specifically, on the pathways of secondary IgE responses. Throughout, we identify areas of future research which will help identify immunotargets for a transformative therapy for food allergy. Dove 2021-06-09 /pmc/articles/PMC8200165/ /pubmed/34136419 http://dx.doi.org/10.2147/ITT.S284823 Text en © 2021 Koenig et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). |
spellingShingle | Review Koenig, Joshua F E Bruton, Kelly Phelps, Allyssa Grydziuszko, Emily Jiménez-Saiz, Rodrigo Jordana, Manel Memory Generation and Re-Activation in Food Allergy |
title | Memory Generation and Re-Activation in Food Allergy |
title_full | Memory Generation and Re-Activation in Food Allergy |
title_fullStr | Memory Generation and Re-Activation in Food Allergy |
title_full_unstemmed | Memory Generation and Re-Activation in Food Allergy |
title_short | Memory Generation and Re-Activation in Food Allergy |
title_sort | memory generation and re-activation in food allergy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200165/ https://www.ncbi.nlm.nih.gov/pubmed/34136419 http://dx.doi.org/10.2147/ITT.S284823 |
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