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Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy

As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved me...

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Autores principales: Grapa, Cristiana Maria, Mocan, Lucian, Crisan, Dana, Florea, Mira, Mocan, Teodora
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200189/
https://www.ncbi.nlm.nih.gov/pubmed/34199998
http://dx.doi.org/10.3390/ma14113083
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author Grapa, Cristiana Maria
Mocan, Lucian
Crisan, Dana
Florea, Mira
Mocan, Teodora
author_facet Grapa, Cristiana Maria
Mocan, Lucian
Crisan, Dana
Florea, Mira
Mocan, Teodora
author_sort Grapa, Cristiana Maria
collection PubMed
description As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved method for early detection, extended asymptomatic state, limited treatment options, poor chemotherapy response and dense tumor stroma that impedes drug delivery. We provide a narrative review of our main findings in the field of nanoparticle directed treatment for PC, with a focus on biomarker targeted delivery. By reducing drug toxicity, increasing their tumor accumulation, ability to modulate tumor microenvironment and even improve imaging contrast, it seems that nanotechnology may one day give hope for better outcome in pancreatic cancer. Further conjugating nanoparticles with biomarkers that are overexpressed amplifies the benefits mentioned, with potential increase in survival and treatment response.
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spelling pubmed-82001892021-06-14 Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy Grapa, Cristiana Maria Mocan, Lucian Crisan, Dana Florea, Mira Mocan, Teodora Materials (Basel) Review As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved method for early detection, extended asymptomatic state, limited treatment options, poor chemotherapy response and dense tumor stroma that impedes drug delivery. We provide a narrative review of our main findings in the field of nanoparticle directed treatment for PC, with a focus on biomarker targeted delivery. By reducing drug toxicity, increasing their tumor accumulation, ability to modulate tumor microenvironment and even improve imaging contrast, it seems that nanotechnology may one day give hope for better outcome in pancreatic cancer. Further conjugating nanoparticles with biomarkers that are overexpressed amplifies the benefits mentioned, with potential increase in survival and treatment response. MDPI 2021-06-04 /pmc/articles/PMC8200189/ /pubmed/34199998 http://dx.doi.org/10.3390/ma14113083 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Grapa, Cristiana Maria
Mocan, Lucian
Crisan, Dana
Florea, Mira
Mocan, Teodora
Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
title Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
title_full Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
title_fullStr Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
title_full_unstemmed Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
title_short Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
title_sort biomarkers in pancreatic cancer as analytic targets for nanomediated imaging and therapy
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200189/
https://www.ncbi.nlm.nih.gov/pubmed/34199998
http://dx.doi.org/10.3390/ma14113083
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