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Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy
As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved me...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200189/ https://www.ncbi.nlm.nih.gov/pubmed/34199998 http://dx.doi.org/10.3390/ma14113083 |
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author | Grapa, Cristiana Maria Mocan, Lucian Crisan, Dana Florea, Mira Mocan, Teodora |
author_facet | Grapa, Cristiana Maria Mocan, Lucian Crisan, Dana Florea, Mira Mocan, Teodora |
author_sort | Grapa, Cristiana Maria |
collection | PubMed |
description | As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved method for early detection, extended asymptomatic state, limited treatment options, poor chemotherapy response and dense tumor stroma that impedes drug delivery. We provide a narrative review of our main findings in the field of nanoparticle directed treatment for PC, with a focus on biomarker targeted delivery. By reducing drug toxicity, increasing their tumor accumulation, ability to modulate tumor microenvironment and even improve imaging contrast, it seems that nanotechnology may one day give hope for better outcome in pancreatic cancer. Further conjugating nanoparticles with biomarkers that are overexpressed amplifies the benefits mentioned, with potential increase in survival and treatment response. |
format | Online Article Text |
id | pubmed-8200189 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82001892021-06-14 Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy Grapa, Cristiana Maria Mocan, Lucian Crisan, Dana Florea, Mira Mocan, Teodora Materials (Basel) Review As the increase in therapeutic and imaging technologies is swiftly improving survival chances for cancer patients, pancreatic cancer (PC) still has a grim prognosis and a rising incidence. Practically everything distinguishing for this type of malignancy makes it challenging to treat: no approved method for early detection, extended asymptomatic state, limited treatment options, poor chemotherapy response and dense tumor stroma that impedes drug delivery. We provide a narrative review of our main findings in the field of nanoparticle directed treatment for PC, with a focus on biomarker targeted delivery. By reducing drug toxicity, increasing their tumor accumulation, ability to modulate tumor microenvironment and even improve imaging contrast, it seems that nanotechnology may one day give hope for better outcome in pancreatic cancer. Further conjugating nanoparticles with biomarkers that are overexpressed amplifies the benefits mentioned, with potential increase in survival and treatment response. MDPI 2021-06-04 /pmc/articles/PMC8200189/ /pubmed/34199998 http://dx.doi.org/10.3390/ma14113083 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Grapa, Cristiana Maria Mocan, Lucian Crisan, Dana Florea, Mira Mocan, Teodora Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
title | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
title_full | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
title_fullStr | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
title_full_unstemmed | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
title_short | Biomarkers in Pancreatic Cancer as Analytic Targets for Nanomediated Imaging and Therapy |
title_sort | biomarkers in pancreatic cancer as analytic targets for nanomediated imaging and therapy |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200189/ https://www.ncbi.nlm.nih.gov/pubmed/34199998 http://dx.doi.org/10.3390/ma14113083 |
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