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A multifaceted role of progranulin in regulating amyloid-beta dynamics and responses

Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal lobar degeneration (FTLD). PGRN polymorphisms are associated with Alzheimer’s disease. PGRN is highly expressed in the microglia near Aβ plaques and influences plaque dynamics and microglial activation. However, the detail...

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Detalles Bibliográficos
Autores principales:	Du, Huan, Wong, Man Ying, Zhang, Tingting, Santos, Mariela Nunez, Hsu, Charlene, Zhang, Junke, Yu, Haiyuan, Luo, Wenjie, Hu, Fenghua
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Life Science Alliance LLC 2021
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200295/ https://www.ncbi.nlm.nih.gov/pubmed/34103390 http://dx.doi.org/10.26508/lsa.202000874

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