Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong

BACKGROUND: Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong. OBJECTIVE: Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases. STUDY DESIGN: SARS-CoV-...

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Autores principales: Tsang, Alan K.L., Mak, Gannon C.K., Cheng, Peter K.C., Yip, Peter C.W., Ng, Ken H.L., Lam, Edman T.K., Chan, Rickjason C.W., Tsang, Dominic N.C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Authors. Published by Elsevier Ltd. 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200330/
https://www.ncbi.nlm.nih.gov/pubmed/35262015
http://dx.doi.org/10.1016/j.jcvp.2021.100029
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author Tsang, Alan K.L.
Mak, Gannon C.K.
Cheng, Peter K.C.
Yip, Peter C.W.
Ng, Ken H.L.
Lam, Edman T.K.
Chan, Rickjason C.W.
Tsang, Dominic N.C.
author_facet Tsang, Alan K.L.
Mak, Gannon C.K.
Cheng, Peter K.C.
Yip, Peter C.W.
Ng, Ken H.L.
Lam, Edman T.K.
Chan, Rickjason C.W.
Tsang, Dominic N.C.
author_sort Tsang, Alan K.L.
collection PubMed
description BACKGROUND: Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong. OBJECTIVE: Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases. STUDY DESIGN: SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays. Preliminary positive cases were further tested by whole genome sequencing. RESULTS: From Dec 2020 to May 2021, 55 SARS-CoV-2 cases belonged to lineage B.1.351. Among them, eight genomes were clustered together, all of them were local cases with epidemiological link. CONCLUSIONS: To track variants of SARS-CoV-2 and to allow early implementation of control measures, SARS-CoV-2 genomic surveillance must be consistently performed.
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spelling pubmed-82003302021-06-15 Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong Tsang, Alan K.L. Mak, Gannon C.K. Cheng, Peter K.C. Yip, Peter C.W. Ng, Ken H.L. Lam, Edman T.K. Chan, Rickjason C.W. Tsang, Dominic N.C. Journal of Clinical Virology Plus Article BACKGROUND: Prior to this report, variants of concern for SARS-CoV-2 were only detected from imported cases in Hong Kong. OBJECTIVE: Multiple cases of SARS-CoV-2 lineage B.1.351 have been identified in local community. We reported the phylogenetic relationship of these cases. STUDY DESIGN: SARS-CoV-2 cases were screened for the key non-synonymous substitutions in spike protein by different assays. Preliminary positive cases were further tested by whole genome sequencing. RESULTS: From Dec 2020 to May 2021, 55 SARS-CoV-2 cases belonged to lineage B.1.351. Among them, eight genomes were clustered together, all of them were local cases with epidemiological link. CONCLUSIONS: To track variants of SARS-CoV-2 and to allow early implementation of control measures, SARS-CoV-2 genomic surveillance must be consistently performed. The Authors. Published by Elsevier Ltd. 2021-09 2021-06-14 /pmc/articles/PMC8200330/ /pubmed/35262015 http://dx.doi.org/10.1016/j.jcvp.2021.100029 Text en © 2021 The Authors Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active.
spellingShingle Article
Tsang, Alan K.L.
Mak, Gannon C.K.
Cheng, Peter K.C.
Yip, Peter C.W.
Ng, Ken H.L.
Lam, Edman T.K.
Chan, Rickjason C.W.
Tsang, Dominic N.C.
Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
title Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
title_full Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
title_fullStr Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
title_full_unstemmed Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
title_short Early detection of community acquired of SARS-CoV-2 lineage B.1.351 in Hong Kong
title_sort early detection of community acquired of sars-cov-2 lineage b.1.351 in hong kong
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200330/
https://www.ncbi.nlm.nih.gov/pubmed/35262015
http://dx.doi.org/10.1016/j.jcvp.2021.100029
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