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The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study

Recent studies have accumulated evidence that the intestinal environment is strongly correlated with host diet, which influences host health. A number of dietary products whose mechanisms of influence operate via the gut microbiota have been revealed, but they are still limited. Here, we investigate...

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Autores principales: Nishimoto, Yuichiro, Nomaguchi, Tatsuhiro, Mori, Yuka, Ito, Masaki, Nakamura, Yuya, Fujishima, Masaki, Murakami, Shinnosuke, Yamada, Takuji, Fukuda, Shinji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200412/
https://www.ncbi.nlm.nih.gov/pubmed/34136514
http://dx.doi.org/10.3389/fnut.2021.648073
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author Nishimoto, Yuichiro
Nomaguchi, Tatsuhiro
Mori, Yuka
Ito, Masaki
Nakamura, Yuya
Fujishima, Masaki
Murakami, Shinnosuke
Yamada, Takuji
Fukuda, Shinji
author_facet Nishimoto, Yuichiro
Nomaguchi, Tatsuhiro
Mori, Yuka
Ito, Masaki
Nakamura, Yuya
Fujishima, Masaki
Murakami, Shinnosuke
Yamada, Takuji
Fukuda, Shinji
author_sort Nishimoto, Yuichiro
collection PubMed
description Recent studies have accumulated evidence that the intestinal environment is strongly correlated with host diet, which influences host health. A number of dietary products whose mechanisms of influence operate via the gut microbiota have been revealed, but they are still limited. Here, we investigated the dietary influence of Chlorella, a green alga commercially available as a dietary supplement. A randomised, double-blind, placebo-controlled crossover trial including 40 Japanese participants with constipation was performed. In this study, the primary outcome and secondary outcome were set as defecation frequency and blood folate level, respectively. In both outcomes, no significant differences were detected compared to the control intake. Therefore, we analysed the gut microbiome, gut metabolome, and blood parameters in an integrated manner as an exploratory analysis. We revealed that the consumption of Chlorella increased the level of several dicarboxylic acids in faeces. Furthermore, the analysis showed that individuals with low concentrations of faecal propionate showed an increase in propionate concentration upon Chlorella intake. In addition, increasing blood folate levels were negatively correlated with defecation frequency at baseline. Our study suggested that the effect of Chlorella consumption varies among individuals depending on their intestinal environment, which illustrates the importance of stratified dietary management based on the intestinal environment in individuals.
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spelling pubmed-82004122021-06-15 The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study Nishimoto, Yuichiro Nomaguchi, Tatsuhiro Mori, Yuka Ito, Masaki Nakamura, Yuya Fujishima, Masaki Murakami, Shinnosuke Yamada, Takuji Fukuda, Shinji Front Nutr Nutrition Recent studies have accumulated evidence that the intestinal environment is strongly correlated with host diet, which influences host health. A number of dietary products whose mechanisms of influence operate via the gut microbiota have been revealed, but they are still limited. Here, we investigated the dietary influence of Chlorella, a green alga commercially available as a dietary supplement. A randomised, double-blind, placebo-controlled crossover trial including 40 Japanese participants with constipation was performed. In this study, the primary outcome and secondary outcome were set as defecation frequency and blood folate level, respectively. In both outcomes, no significant differences were detected compared to the control intake. Therefore, we analysed the gut microbiome, gut metabolome, and blood parameters in an integrated manner as an exploratory analysis. We revealed that the consumption of Chlorella increased the level of several dicarboxylic acids in faeces. Furthermore, the analysis showed that individuals with low concentrations of faecal propionate showed an increase in propionate concentration upon Chlorella intake. In addition, increasing blood folate levels were negatively correlated with defecation frequency at baseline. Our study suggested that the effect of Chlorella consumption varies among individuals depending on their intestinal environment, which illustrates the importance of stratified dietary management based on the intestinal environment in individuals. Frontiers Media S.A. 2021-05-31 /pmc/articles/PMC8200412/ /pubmed/34136514 http://dx.doi.org/10.3389/fnut.2021.648073 Text en Copyright © 2021 Nishimoto, Nomaguchi, Mori, Ito, Nakamura, Fujishima, Murakami, Yamada and Fukuda. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Nutrition
Nishimoto, Yuichiro
Nomaguchi, Tatsuhiro
Mori, Yuka
Ito, Masaki
Nakamura, Yuya
Fujishima, Masaki
Murakami, Shinnosuke
Yamada, Takuji
Fukuda, Shinji
The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study
title The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study
title_full The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study
title_fullStr The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study
title_full_unstemmed The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study
title_short The Nutritional Efficacy of Chlorella Supplementation Depends on the Individual Gut Environment: A Randomised Control Study
title_sort nutritional efficacy of chlorella supplementation depends on the individual gut environment: a randomised control study
topic Nutrition
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200412/
https://www.ncbi.nlm.nih.gov/pubmed/34136514
http://dx.doi.org/10.3389/fnut.2021.648073
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