The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues

Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and p...

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Detalles Bibliográficos
Autores principales: Yang, Ya, Zhao, Yalei, Zhang, Lingjian, Zhang, Fen, Li, Lanjuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200416/
https://www.ncbi.nlm.nih.gov/pubmed/34136500
http://dx.doi.org/10.3389/fmed.2021.655268
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author Yang, Ya
Zhao, Yalei
Zhang, Lingjian
Zhang, Fen
Li, Lanjuan
author_facet Yang, Ya
Zhao, Yalei
Zhang, Lingjian
Zhang, Fen
Li, Lanjuan
author_sort Yang, Ya
collection PubMed
description Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and preliminary clinical trials, issues remain. The efficacy and safety of MSC-based therapy in the treatment of liver diseases remains a challenging issue that requires more investigation. This article reviews recent studies on the mechanisms of MSCs in liver diseases and the associated challenges and suggests potential future applications.
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spelling pubmed-82004162021-06-15 The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues Yang, Ya Zhao, Yalei Zhang, Lingjian Zhang, Fen Li, Lanjuan Front Med (Lausanne) Medicine Mesenchymal stem cell (MSC) transplantation is a novel treatment for liver diseases due to the roles of MSCs in regeneration, fibrosis inhibition and immune regulation. However, the mechanisms are still not completely understood. Despite the significant efficacy of MSC therapy in animal models and preliminary clinical trials, issues remain. The efficacy and safety of MSC-based therapy in the treatment of liver diseases remains a challenging issue that requires more investigation. This article reviews recent studies on the mechanisms of MSCs in liver diseases and the associated challenges and suggests potential future applications. Frontiers Media S.A. 2021-05-31 /pmc/articles/PMC8200416/ /pubmed/34136500 http://dx.doi.org/10.3389/fmed.2021.655268 Text en Copyright © 2021 Yang, Zhao, Zhang, Zhang and Li. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Yang, Ya
Zhao, Yalei
Zhang, Lingjian
Zhang, Fen
Li, Lanjuan
The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues
title The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues
title_full The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues
title_fullStr The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues
title_full_unstemmed The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues
title_short The Application of Mesenchymal Stem Cells in the Treatment of Liver Diseases: Mechanism, Efficacy, and Safety Issues
title_sort application of mesenchymal stem cells in the treatment of liver diseases: mechanism, efficacy, and safety issues
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200416/
https://www.ncbi.nlm.nih.gov/pubmed/34136500
http://dx.doi.org/10.3389/fmed.2021.655268
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