Cargando…

Dosimetry with a clinical linac adapted to FLASH electron beams

PURPOSE: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra‐high dose rate) electron mode. METHODS: An 18MV photon beam of a Varian iX linac was converted...

Descripción completa

Detalles Bibliográficos
Autores principales: Szpala, Stanislaw, Huang, Vicky, Zhao, Yingli, Kyle, Alastair, Minchinton, Andrew, Karan, Tania, Kohli, Kirpal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200504/
https://www.ncbi.nlm.nih.gov/pubmed/34028969
http://dx.doi.org/10.1002/acm2.13270
_version_ 1783707618712223744
author Szpala, Stanislaw
Huang, Vicky
Zhao, Yingli
Kyle, Alastair
Minchinton, Andrew
Karan, Tania
Kohli, Kirpal
author_facet Szpala, Stanislaw
Huang, Vicky
Zhao, Yingli
Kyle, Alastair
Minchinton, Andrew
Karan, Tania
Kohli, Kirpal
author_sort Szpala, Stanislaw
collection PubMed
description PURPOSE: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra‐high dose rate) electron mode. METHODS: An 18MV photon beam of a Varian iX linac was converted to FLASH electron beam by replacing the target and the flattening filter with an electron scattering foil. The dose was prescribed by entering the MUs through the console. Fundamental beam properties, including energy, dose rate, dose reproducibility, field size, and dose rate dependence on the SAD, were examined in preparation for radiobiological experiments. Gafchromic EBT‐XD film was evaluated for usability in measurements at ultra‐high dose rates by comparing the measured dose to the inverse square model. Selected previously reported models of chamber efficiencies were fitted to measurements in a broad range of dose rates. RESULTS: The performance of the modified linac was found adequate for FLASH radiobiological experiments. With exception of the increase in the dose per MU on increase in the repetition rate, all fundamental beam properties proved to be in line with expectations developed with conventional linacs. The field size followed the theorem of similar triangles. The highest average dose rate (2 × 10(4) Gy/s) was found next to the internal monitor chamber, with the field size of FWHM = 1.5 cm. Independence of the dose readings on the dose rate (up to 2 × 10(4) Gy/s) was demonstrated for the EBT‐XD film. A model of recombination in an ionization chamber was identified that provided good agreement with the measured chamber efficiencies for the average dose rates up to at least 2 × 10(3) Gy/s. CONCLUSION: Dosimetric measurements were performed to characterize a linac converted to FLASH dose rates. Gafchromic EBT‐XD film and dose rate‐corrected cc13 ionization chamber were demonstrated usable at FLASH dose rates.
format Online
Article
Text
id pubmed-8200504
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-82005042021-06-15 Dosimetry with a clinical linac adapted to FLASH electron beams Szpala, Stanislaw Huang, Vicky Zhao, Yingli Kyle, Alastair Minchinton, Andrew Karan, Tania Kohli, Kirpal J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra‐high dose rate) electron mode. METHODS: An 18MV photon beam of a Varian iX linac was converted to FLASH electron beam by replacing the target and the flattening filter with an electron scattering foil. The dose was prescribed by entering the MUs through the console. Fundamental beam properties, including energy, dose rate, dose reproducibility, field size, and dose rate dependence on the SAD, were examined in preparation for radiobiological experiments. Gafchromic EBT‐XD film was evaluated for usability in measurements at ultra‐high dose rates by comparing the measured dose to the inverse square model. Selected previously reported models of chamber efficiencies were fitted to measurements in a broad range of dose rates. RESULTS: The performance of the modified linac was found adequate for FLASH radiobiological experiments. With exception of the increase in the dose per MU on increase in the repetition rate, all fundamental beam properties proved to be in line with expectations developed with conventional linacs. The field size followed the theorem of similar triangles. The highest average dose rate (2 × 10(4) Gy/s) was found next to the internal monitor chamber, with the field size of FWHM = 1.5 cm. Independence of the dose readings on the dose rate (up to 2 × 10(4) Gy/s) was demonstrated for the EBT‐XD film. A model of recombination in an ionization chamber was identified that provided good agreement with the measured chamber efficiencies for the average dose rates up to at least 2 × 10(3) Gy/s. CONCLUSION: Dosimetric measurements were performed to characterize a linac converted to FLASH dose rates. Gafchromic EBT‐XD film and dose rate‐corrected cc13 ionization chamber were demonstrated usable at FLASH dose rates. John Wiley and Sons Inc. 2021-05-24 /pmc/articles/PMC8200504/ /pubmed/34028969 http://dx.doi.org/10.1002/acm2.13270 Text en © 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Radiation Oncology Physics
Szpala, Stanislaw
Huang, Vicky
Zhao, Yingli
Kyle, Alastair
Minchinton, Andrew
Karan, Tania
Kohli, Kirpal
Dosimetry with a clinical linac adapted to FLASH electron beams
title Dosimetry with a clinical linac adapted to FLASH electron beams
title_full Dosimetry with a clinical linac adapted to FLASH electron beams
title_fullStr Dosimetry with a clinical linac adapted to FLASH electron beams
title_full_unstemmed Dosimetry with a clinical linac adapted to FLASH electron beams
title_short Dosimetry with a clinical linac adapted to FLASH electron beams
title_sort dosimetry with a clinical linac adapted to flash electron beams
topic Radiation Oncology Physics
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200504/
https://www.ncbi.nlm.nih.gov/pubmed/34028969
http://dx.doi.org/10.1002/acm2.13270
work_keys_str_mv AT szpalastanislaw dosimetrywithaclinicallinacadaptedtoflashelectronbeams
AT huangvicky dosimetrywithaclinicallinacadaptedtoflashelectronbeams
AT zhaoyingli dosimetrywithaclinicallinacadaptedtoflashelectronbeams
AT kylealastair dosimetrywithaclinicallinacadaptedtoflashelectronbeams
AT minchintonandrew dosimetrywithaclinicallinacadaptedtoflashelectronbeams
AT karantania dosimetrywithaclinicallinacadaptedtoflashelectronbeams
AT kohlikirpal dosimetrywithaclinicallinacadaptedtoflashelectronbeams