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Dosimetry with a clinical linac adapted to FLASH electron beams
PURPOSE: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra‐high dose rate) electron mode. METHODS: An 18MV photon beam of a Varian iX linac was converted...
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200504/ https://www.ncbi.nlm.nih.gov/pubmed/34028969 http://dx.doi.org/10.1002/acm2.13270 |
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author | Szpala, Stanislaw Huang, Vicky Zhao, Yingli Kyle, Alastair Minchinton, Andrew Karan, Tania Kohli, Kirpal |
author_facet | Szpala, Stanislaw Huang, Vicky Zhao, Yingli Kyle, Alastair Minchinton, Andrew Karan, Tania Kohli, Kirpal |
author_sort | Szpala, Stanislaw |
collection | PubMed |
description | PURPOSE: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra‐high dose rate) electron mode. METHODS: An 18MV photon beam of a Varian iX linac was converted to FLASH electron beam by replacing the target and the flattening filter with an electron scattering foil. The dose was prescribed by entering the MUs through the console. Fundamental beam properties, including energy, dose rate, dose reproducibility, field size, and dose rate dependence on the SAD, were examined in preparation for radiobiological experiments. Gafchromic EBT‐XD film was evaluated for usability in measurements at ultra‐high dose rates by comparing the measured dose to the inverse square model. Selected previously reported models of chamber efficiencies were fitted to measurements in a broad range of dose rates. RESULTS: The performance of the modified linac was found adequate for FLASH radiobiological experiments. With exception of the increase in the dose per MU on increase in the repetition rate, all fundamental beam properties proved to be in line with expectations developed with conventional linacs. The field size followed the theorem of similar triangles. The highest average dose rate (2 × 10(4) Gy/s) was found next to the internal monitor chamber, with the field size of FWHM = 1.5 cm. Independence of the dose readings on the dose rate (up to 2 × 10(4) Gy/s) was demonstrated for the EBT‐XD film. A model of recombination in an ionization chamber was identified that provided good agreement with the measured chamber efficiencies for the average dose rates up to at least 2 × 10(3) Gy/s. CONCLUSION: Dosimetric measurements were performed to characterize a linac converted to FLASH dose rates. Gafchromic EBT‐XD film and dose rate‐corrected cc13 ionization chamber were demonstrated usable at FLASH dose rates. |
format | Online Article Text |
id | pubmed-8200504 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82005042021-06-15 Dosimetry with a clinical linac adapted to FLASH electron beams Szpala, Stanislaw Huang, Vicky Zhao, Yingli Kyle, Alastair Minchinton, Andrew Karan, Tania Kohli, Kirpal J Appl Clin Med Phys Radiation Oncology Physics PURPOSE: To assess dosimetric properties and identify required updates to commonly used protocols (including use of film and ionization chamber) pertaining to a clinical linac configured into FLASH (ultra‐high dose rate) electron mode. METHODS: An 18MV photon beam of a Varian iX linac was converted to FLASH electron beam by replacing the target and the flattening filter with an electron scattering foil. The dose was prescribed by entering the MUs through the console. Fundamental beam properties, including energy, dose rate, dose reproducibility, field size, and dose rate dependence on the SAD, were examined in preparation for radiobiological experiments. Gafchromic EBT‐XD film was evaluated for usability in measurements at ultra‐high dose rates by comparing the measured dose to the inverse square model. Selected previously reported models of chamber efficiencies were fitted to measurements in a broad range of dose rates. RESULTS: The performance of the modified linac was found adequate for FLASH radiobiological experiments. With exception of the increase in the dose per MU on increase in the repetition rate, all fundamental beam properties proved to be in line with expectations developed with conventional linacs. The field size followed the theorem of similar triangles. The highest average dose rate (2 × 10(4) Gy/s) was found next to the internal monitor chamber, with the field size of FWHM = 1.5 cm. Independence of the dose readings on the dose rate (up to 2 × 10(4) Gy/s) was demonstrated for the EBT‐XD film. A model of recombination in an ionization chamber was identified that provided good agreement with the measured chamber efficiencies for the average dose rates up to at least 2 × 10(3) Gy/s. CONCLUSION: Dosimetric measurements were performed to characterize a linac converted to FLASH dose rates. Gafchromic EBT‐XD film and dose rate‐corrected cc13 ionization chamber were demonstrated usable at FLASH dose rates. John Wiley and Sons Inc. 2021-05-24 /pmc/articles/PMC8200504/ /pubmed/34028969 http://dx.doi.org/10.1002/acm2.13270 Text en © 2021 The Authors. Journal of Applied Clinical Medical Physics published by Wiley Periodicals LLC on behalf of American Association of Physicists in Medicine https://creativecommons.org/licenses/by/4.0/This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Radiation Oncology Physics Szpala, Stanislaw Huang, Vicky Zhao, Yingli Kyle, Alastair Minchinton, Andrew Karan, Tania Kohli, Kirpal Dosimetry with a clinical linac adapted to FLASH electron beams |
title | Dosimetry with a clinical linac adapted to FLASH electron beams |
title_full | Dosimetry with a clinical linac adapted to FLASH electron beams |
title_fullStr | Dosimetry with a clinical linac adapted to FLASH electron beams |
title_full_unstemmed | Dosimetry with a clinical linac adapted to FLASH electron beams |
title_short | Dosimetry with a clinical linac adapted to FLASH electron beams |
title_sort | dosimetry with a clinical linac adapted to flash electron beams |
topic | Radiation Oncology Physics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200504/ https://www.ncbi.nlm.nih.gov/pubmed/34028969 http://dx.doi.org/10.1002/acm2.13270 |
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