Cargando…
The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant
Hypertensive disorders of pregnancy, including preeclampsia, affect nearly 10% of all pregnancies and are associated with significant long-term detrimental effects on both maternal and offspring cardiovascular health. Current management of preeclampsia involves timely delivery with the more severe f...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200529/ https://www.ncbi.nlm.nih.gov/pubmed/34136436 http://dx.doi.org/10.3389/fped.2021.625726 |
_version_ | 1783707624947056640 |
---|---|
author | Frost, Annabelle L. Suriano, Katie Aye, Christina Y. L. Leeson, Paul Lewandowski, Adam J. |
author_facet | Frost, Annabelle L. Suriano, Katie Aye, Christina Y. L. Leeson, Paul Lewandowski, Adam J. |
author_sort | Frost, Annabelle L. |
collection | PubMed |
description | Hypertensive disorders of pregnancy, including preeclampsia, affect nearly 10% of all pregnancies and are associated with significant long-term detrimental effects on both maternal and offspring cardiovascular health. Current management of preeclampsia involves timely delivery with the more severe form of disease requiring iatrogenic preterm birth. The effects on the maternal cardiovascular system have been studied extensively; however, less is known about the short- and long-term impacts on offspring cardiovascular health. There is a growing body of evidence suggesting that the offspring of pre-eclamptic pregnancies have an altered cardiac structure and function, along with a unique vascular physiology driven by lower endothelial function. Many of these changes can also be seen in those born preterm even in the absence of pregnancy hypertension. It is difficult to determine the relative contribution of pre-maturity and preeclampsia to the cardiovascular phenotype of those exposed to these pregnancy complications as they are, in many cases, inextricably linked. This review, therefore, focuses specifically on the evidence from clinical studies showing a negative cardiovascular impact of preeclampsia in preterm-born offspring, investigating phenotypic similarities and differences between offspring born preterm to normotensive vs. pre-eclamptic pregnancies. We explore the unique cardiac and vascular alterations in pre-eclamptic offspring born preterm, highlighting knowledge gaps, and potential areas of further research in the field. |
format | Online Article Text |
id | pubmed-8200529 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-82005292021-06-15 The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant Frost, Annabelle L. Suriano, Katie Aye, Christina Y. L. Leeson, Paul Lewandowski, Adam J. Front Pediatr Pediatrics Hypertensive disorders of pregnancy, including preeclampsia, affect nearly 10% of all pregnancies and are associated with significant long-term detrimental effects on both maternal and offspring cardiovascular health. Current management of preeclampsia involves timely delivery with the more severe form of disease requiring iatrogenic preterm birth. The effects on the maternal cardiovascular system have been studied extensively; however, less is known about the short- and long-term impacts on offspring cardiovascular health. There is a growing body of evidence suggesting that the offspring of pre-eclamptic pregnancies have an altered cardiac structure and function, along with a unique vascular physiology driven by lower endothelial function. Many of these changes can also be seen in those born preterm even in the absence of pregnancy hypertension. It is difficult to determine the relative contribution of pre-maturity and preeclampsia to the cardiovascular phenotype of those exposed to these pregnancy complications as they are, in many cases, inextricably linked. This review, therefore, focuses specifically on the evidence from clinical studies showing a negative cardiovascular impact of preeclampsia in preterm-born offspring, investigating phenotypic similarities and differences between offspring born preterm to normotensive vs. pre-eclamptic pregnancies. We explore the unique cardiac and vascular alterations in pre-eclamptic offspring born preterm, highlighting knowledge gaps, and potential areas of further research in the field. Frontiers Media S.A. 2021-05-31 /pmc/articles/PMC8200529/ /pubmed/34136436 http://dx.doi.org/10.3389/fped.2021.625726 Text en Copyright © 2021 Frost, Suriano, Aye, Leeson and Lewandowski. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Pediatrics Frost, Annabelle L. Suriano, Katie Aye, Christina Y. L. Leeson, Paul Lewandowski, Adam J. The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant |
title | The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant |
title_full | The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant |
title_fullStr | The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant |
title_full_unstemmed | The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant |
title_short | The Immediate and Long-Term Impact of Preeclampsia on Offspring Vascular and Cardiac Physiology in the Preterm Infant |
title_sort | immediate and long-term impact of preeclampsia on offspring vascular and cardiac physiology in the preterm infant |
topic | Pediatrics |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200529/ https://www.ncbi.nlm.nih.gov/pubmed/34136436 http://dx.doi.org/10.3389/fped.2021.625726 |
work_keys_str_mv | AT frostannabellel theimmediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT surianokatie theimmediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT ayechristinayl theimmediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT leesonpaul theimmediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT lewandowskiadamj theimmediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT frostannabellel immediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT surianokatie immediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT ayechristinayl immediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT leesonpaul immediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant AT lewandowskiadamj immediateandlongtermimpactofpreeclampsiaonoffspringvascularandcardiacphysiologyinthepreterminfant |