Cargando…

C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits

Background: Stroke diagnosis can be challenging in patients with dizziness without neurologic deficits. The aim of this study was to evaluate the predictive value of C-reactive protein (CRP) for identifying acute stroke in such patients. Methods: Data from adult patients (>18 years) admitted to t...

Descripción completa

Detalles Bibliográficos
Autores principales: Hong, Seok-In, Kim, June-Sung, Bae, Hong Jun, Kim, Won Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200534/
https://www.ncbi.nlm.nih.gov/pubmed/34135849
http://dx.doi.org/10.3389/fneur.2021.662510
_version_ 1783707626121461760
author Hong, Seok-In
Kim, June-Sung
Bae, Hong Jun
Kim, Won Young
author_facet Hong, Seok-In
Kim, June-Sung
Bae, Hong Jun
Kim, Won Young
author_sort Hong, Seok-In
collection PubMed
description Background: Stroke diagnosis can be challenging in patients with dizziness without neurologic deficits. The aim of this study was to evaluate the predictive value of C-reactive protein (CRP) for identifying acute stroke in such patients. Methods: Data from adult patients (>18 years) admitted to the emergency department from August 2019 to February 2020 were evaluated. The study subjects were 1,188 patients presenting with dizziness without neurological deficits whose serum CRP level was measured within 2 h of arriving at the emergency department and who underwent brain magnetic resonance imaging. The relationship between CRP and acute stroke was analyzed using univariable and multivariable models. Results: Acute stroke was detected in 53 (4.4%) patients (40 with brain infarction, 10 with vertebrobasilar insufficiency, 2 with intracerebral hemorrhage, and 1 with subarachnoid hemorrhage). The CRP levels did not differ significantly between the acute stroke and non-stroke groups [0.10 (0.10–0.31) vs. 0.10 (0.10–0.16), P = 0.074]. The area under receiver operating characteristic curve of CRP for acute stroke was not statistically significant (0.567, P = 0.101). On multivariable analysis, the following variables were associated with acute stroke: age (odds ratio [OR], 1.041; 95% confidence interval [CI], 1.011–1.071), history of cerebrovascular accidents (OR, 1.823; 95% CI, 1.068–3.110), white blood cell count (OR, 1.126; 95% CI, 1.017–1.248), and hemoglobin (OR, 1.316; 95% CI, 1.056–1.640). However, CRP (P = 0.183) was not associated with acute stroke. Conclusion: Serum CRP levels do not have significant discriminative value for identifying acute stroke in patients with dizziness without definite neurologic deficits.
format Online
Article
Text
id pubmed-8200534
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-82005342021-06-15 C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits Hong, Seok-In Kim, June-Sung Bae, Hong Jun Kim, Won Young Front Neurol Neurology Background: Stroke diagnosis can be challenging in patients with dizziness without neurologic deficits. The aim of this study was to evaluate the predictive value of C-reactive protein (CRP) for identifying acute stroke in such patients. Methods: Data from adult patients (>18 years) admitted to the emergency department from August 2019 to February 2020 were evaluated. The study subjects were 1,188 patients presenting with dizziness without neurological deficits whose serum CRP level was measured within 2 h of arriving at the emergency department and who underwent brain magnetic resonance imaging. The relationship between CRP and acute stroke was analyzed using univariable and multivariable models. Results: Acute stroke was detected in 53 (4.4%) patients (40 with brain infarction, 10 with vertebrobasilar insufficiency, 2 with intracerebral hemorrhage, and 1 with subarachnoid hemorrhage). The CRP levels did not differ significantly between the acute stroke and non-stroke groups [0.10 (0.10–0.31) vs. 0.10 (0.10–0.16), P = 0.074]. The area under receiver operating characteristic curve of CRP for acute stroke was not statistically significant (0.567, P = 0.101). On multivariable analysis, the following variables were associated with acute stroke: age (odds ratio [OR], 1.041; 95% confidence interval [CI], 1.011–1.071), history of cerebrovascular accidents (OR, 1.823; 95% CI, 1.068–3.110), white blood cell count (OR, 1.126; 95% CI, 1.017–1.248), and hemoglobin (OR, 1.316; 95% CI, 1.056–1.640). However, CRP (P = 0.183) was not associated with acute stroke. Conclusion: Serum CRP levels do not have significant discriminative value for identifying acute stroke in patients with dizziness without definite neurologic deficits. Frontiers Media S.A. 2021-05-31 /pmc/articles/PMC8200534/ /pubmed/34135849 http://dx.doi.org/10.3389/fneur.2021.662510 Text en Copyright © 2021 Hong, Kim, Bae and Kim. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Hong, Seok-In
Kim, June-Sung
Bae, Hong Jun
Kim, Won Young
C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits
title C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits
title_full C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits
title_fullStr C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits
title_full_unstemmed C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits
title_short C-reactive Protein for Stroke Detection in the Emergency Department in Patients With Dizziness Without Neurological Deficits
title_sort c-reactive protein for stroke detection in the emergency department in patients with dizziness without neurological deficits
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200534/
https://www.ncbi.nlm.nih.gov/pubmed/34135849
http://dx.doi.org/10.3389/fneur.2021.662510
work_keys_str_mv AT hongseokin creactiveproteinforstrokedetectionintheemergencydepartmentinpatientswithdizzinesswithoutneurologicaldeficits
AT kimjunesung creactiveproteinforstrokedetectionintheemergencydepartmentinpatientswithdizzinesswithoutneurologicaldeficits
AT baehongjun creactiveproteinforstrokedetectionintheemergencydepartmentinpatientswithdizzinesswithoutneurologicaldeficits
AT kimwonyoung creactiveproteinforstrokedetectionintheemergencydepartmentinpatientswithdizzinesswithoutneurologicaldeficits