VEGF Immunoexpression in Prostate Adenocarcinoma

Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters o...

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Detalles Bibliográficos
Autores principales: PĂNUŞ, ANDREI, SIMIONESCU, CRISTIANA EUGENIA, DRĂGOESCU, PETRU OCTAVIAN, STEPAN, ALEX EMILIAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200605/
https://www.ncbi.nlm.nih.gov/pubmed/34211753
http://dx.doi.org/10.12865/CHSJ.47.01.14
Descripción
Sumario:Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.

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