VEGF Immunoexpression in Prostate Adenocarcinoma

Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters o...

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Autores principales: PĂNUŞ, ANDREI, SIMIONESCU, CRISTIANA EUGENIA, DRĂGOESCU, PETRU OCTAVIAN, STEPAN, ALEX EMILIAN
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Medical University Publishing House Craiova 2021
Materias:
Original Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200605/
https://www.ncbi.nlm.nih.gov/pubmed/34211753
http://dx.doi.org/10.12865/CHSJ.47.01.14
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author PĂNUŞ, ANDREI
SIMIONESCU, CRISTIANA EUGENIA
DRĂGOESCU, PETRU OCTAVIAN
STEPAN, ALEX EMILIAN
author_facet PĂNUŞ, ANDREI
SIMIONESCU, CRISTIANA EUGENIA
DRĂGOESCU, PETRU OCTAVIAN
STEPAN, ALEX EMILIAN
author_sort PĂNUŞ, ANDREI
collection PubMed
description Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions.
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spelling pubmed-82006052021-06-30 VEGF Immunoexpression in Prostate Adenocarcinoma PĂNUŞ, ANDREI SIMIONESCU, CRISTIANA EUGENIA DRĂGOESCU, PETRU OCTAVIAN STEPAN, ALEX EMILIAN Curr Health Sci J Original Paper Angiogenesis is a basic biomolecular mechanism for tumor progression, the vascular endothelial growth factor (VEGF) being one of the main enhancers of this complex process. In this study, we analyzed VEGF-A immunoexpression in 61 prostate adenocarcinomas (PAs), related to the prognostic parameters of the lesions. VEGF scores were higher in PAs that associated serum PSA values above 20ng/ml, in tumors with pure complex or mixed growth patterns, as well as in high-grade and advanced lesions. The results obtained indicate the involvement of VEGF in prostate angiogenesis and the usefulness of the maker for the identification of aggressive lesions. Medical University Publishing House Craiova 2021 2021-03-31 /pmc/articles/PMC8200605/ /pubmed/34211753 http://dx.doi.org/10.12865/CHSJ.47.01.14 Text en Copyright © 2014, Medical University Publishing House Craiova https://creativecommons.org/licenses/by-nc-sa/4.0/This is an open-access article distributed under the terms of a Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International Public License, which permits unrestricted use, adaptation, distribution and reproduction in any medium, non-commercially, provided the new creations are licensed under identical terms as the original work and the original work is properly cited.
spellingShingle Original Paper
PĂNUŞ, ANDREI
SIMIONESCU, CRISTIANA EUGENIA
DRĂGOESCU, PETRU OCTAVIAN
STEPAN, ALEX EMILIAN
VEGF Immunoexpression in Prostate Adenocarcinoma
title VEGF Immunoexpression in Prostate Adenocarcinoma
title_full VEGF Immunoexpression in Prostate Adenocarcinoma
title_fullStr VEGF Immunoexpression in Prostate Adenocarcinoma
title_full_unstemmed VEGF Immunoexpression in Prostate Adenocarcinoma
title_short VEGF Immunoexpression in Prostate Adenocarcinoma
title_sort vegf immunoexpression in prostate adenocarcinoma
topic Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200605/
https://www.ncbi.nlm.nih.gov/pubmed/34211753
http://dx.doi.org/10.12865/CHSJ.47.01.14
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