Discovery of hydroxytyrosol as thioredoxin reductase 1 inhibitor to induce apoptosis and G(1)/S cell cycle arrest in human colorectal cancer cells via ROS generation

Colorectal cancer (CRC) is one of the most common cancer types and a leading cause of cancer-associated mortality in China. Increased thioredoxin reductase 1 (TrxR1) levels have been previously identified as possible target for CRC. The present study revealed that the natural product hydroxytyrosol...

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Detalles Bibliográficos
Autores principales: Zhang, Sheng-Peng, Zhou, Ji, Fan, Qing-Zhu, Lv, Xiao-Mei, Wang, Tian, Wang, Fan, Chen, Yang, Hong, Sen-Yan, Liu, Xiao-Ping, Xu, Bing-Song, Hu, Lei, Zhang, Chao, Zhang, Ye-Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: D.A. Spandidos 2021
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200807/
https://www.ncbi.nlm.nih.gov/pubmed/34149875
http://dx.doi.org/10.3892/etm.2021.10261

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