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Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies

SIMPLE SUMMARY: Since the role of immune evasion was included as a hallmark in cancer, the idea of cancer as a single cell mass that replicate unlimitedly in isolation was dissolved. In this sense, cancer and tumorigenesis cannot be understood without taking into account the tumor microenvironment (...

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Autores principales: Hernández, Ángela-Patricia, Juanes-Velasco, Pablo, Landeira-Viñuela, Alicia, Bareke, Halin, Montalvillo, Enrique, Góngora, Rafael, Fuentes, Manuel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201010/
https://www.ncbi.nlm.nih.gov/pubmed/34198850
http://dx.doi.org/10.3390/cancers13112821
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author Hernández, Ángela-Patricia
Juanes-Velasco, Pablo
Landeira-Viñuela, Alicia
Bareke, Halin
Montalvillo, Enrique
Góngora, Rafael
Fuentes, Manuel
author_facet Hernández, Ángela-Patricia
Juanes-Velasco, Pablo
Landeira-Viñuela, Alicia
Bareke, Halin
Montalvillo, Enrique
Góngora, Rafael
Fuentes, Manuel
author_sort Hernández, Ángela-Patricia
collection PubMed
description SIMPLE SUMMARY: Since the role of immune evasion was included as a hallmark in cancer, the idea of cancer as a single cell mass that replicate unlimitedly in isolation was dissolved. In this sense, cancer and tumorigenesis cannot be understood without taking into account the tumor microenvironment (TME) that plays a crucial role in drug resistance. Immune characteristics of TME can determine the success in treatment at the same time that antitumor therapies can reshape the immunity in TME. Here, we collect a variety of onco-therapies that have been demonstrated to induce an interesting immune response accompanying its pharmacological action that is named as “immunogenic cell death”. As this report shows, immunogenic cell death has been gaining importance in antitumor therapy and should be studied in depth as well as taking into account other applications that may arise from this immune phenomenon. ABSTRACT: Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment. A long-term adaptative immune response can be initiated by modulating cell death by therapeutic approaches. Here, the major hallmarks of ICD, endoplasmic reticulum (ER) stress, and damage-associated molecular patterns (DAMPs) are correlated with ICD inducers used in clinical practice to enhance antitumoral activity by suppressing tumor immune evasion. Approaches to monitoring the ICD triggered by antitumoral therapeutics in the tumor microenvironment (TME) and novel perspective in this immune system strategy are also reviewed to give an overview of the relevance of ICD in cancer treatment.
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spelling pubmed-82010102021-06-15 Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies Hernández, Ángela-Patricia Juanes-Velasco, Pablo Landeira-Viñuela, Alicia Bareke, Halin Montalvillo, Enrique Góngora, Rafael Fuentes, Manuel Cancers (Basel) Review SIMPLE SUMMARY: Since the role of immune evasion was included as a hallmark in cancer, the idea of cancer as a single cell mass that replicate unlimitedly in isolation was dissolved. In this sense, cancer and tumorigenesis cannot be understood without taking into account the tumor microenvironment (TME) that plays a crucial role in drug resistance. Immune characteristics of TME can determine the success in treatment at the same time that antitumor therapies can reshape the immunity in TME. Here, we collect a variety of onco-therapies that have been demonstrated to induce an interesting immune response accompanying its pharmacological action that is named as “immunogenic cell death”. As this report shows, immunogenic cell death has been gaining importance in antitumor therapy and should be studied in depth as well as taking into account other applications that may arise from this immune phenomenon. ABSTRACT: Immunogenic cell death (ICD) elicited by cancer therapy reshapes the tumor immune microenvironment. A long-term adaptative immune response can be initiated by modulating cell death by therapeutic approaches. Here, the major hallmarks of ICD, endoplasmic reticulum (ER) stress, and damage-associated molecular patterns (DAMPs) are correlated with ICD inducers used in clinical practice to enhance antitumoral activity by suppressing tumor immune evasion. Approaches to monitoring the ICD triggered by antitumoral therapeutics in the tumor microenvironment (TME) and novel perspective in this immune system strategy are also reviewed to give an overview of the relevance of ICD in cancer treatment. MDPI 2021-06-05 /pmc/articles/PMC8201010/ /pubmed/34198850 http://dx.doi.org/10.3390/cancers13112821 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Hernández, Ángela-Patricia
Juanes-Velasco, Pablo
Landeira-Viñuela, Alicia
Bareke, Halin
Montalvillo, Enrique
Góngora, Rafael
Fuentes, Manuel
Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
title Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
title_full Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
title_fullStr Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
title_full_unstemmed Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
title_short Restoring the Immunity in the Tumor Microenvironment: Insights into Immunogenic Cell Death in Onco-Therapies
title_sort restoring the immunity in the tumor microenvironment: insights into immunogenic cell death in onco-therapies
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201010/
https://www.ncbi.nlm.nih.gov/pubmed/34198850
http://dx.doi.org/10.3390/cancers13112821
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