Activation of the Integrated Stress Response and ER Stress Protect from Fluorizoline-Induced Apoptosis in HEK293T and U2OS Cell Lines

The prohibitin (PHB)-binding compound fluorizoline as well as PHB-downregulation activate the integrated stress response (ISR) in HEK293T and U2OS human cell lines. This activation is denoted by phosphorylation of eIF2α and increases in ATF4, ATF3, and CHOP protein levels. The blockage of the activa...

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Detalles Bibliográficos
Autores principales: Saura-Esteller, José, Sánchez-Vera, Ismael, Núñez-Vázquez, Sonia, Cosialls, Ana M., Gama-Pérez, Pau, Bhosale, Gauri, Mendive-Tapia, Lorena, Lavilla, Rodolfo, Pons, Gabriel, Garcia-Roves, Pablo M., Duchen, Michael R., Iglesias-Serret, Daniel, Gil, Joan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201103/
https://www.ncbi.nlm.nih.gov/pubmed/34204139
http://dx.doi.org/10.3390/ijms22116117

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