Cargando…
Loss of Nitric Oxide Induces Fibrogenic Response in Organotypic 3D Co-Culture of Mammary Epithelia and Fibroblasts—An Indicator for Breast Carcinogenesis
SIMPLE SUMMARY: Fibrosis, which is often caused by chronic diseases and environmental substances, is closely associated with cancer. Thus, the development of a robust method allowing for deep studies of the linkage between fibrosis and cancer is essential. Here, we tested whether our novel three-dim...
Autores principales: | Ren, Gang, Zheng, Xunzhen, Sharma, Vandana, Letson, Joshua, Nestor-Kalinoski, Andrea L., Furuta, Saori |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201212/ https://www.ncbi.nlm.nih.gov/pubmed/34198735 http://dx.doi.org/10.3390/cancers13112815 |
Ejemplares similares
-
Reduced Basal Nitric Oxide Production Induces Precancerous Mammary Lesions via ERBB2 and TGFβ
por: Ren, Gang, et al.
Publicado: (2019) -
Correction of arginine metabolism with sepiapterin—the precursor of nitric oxide synthase cofactor BH(4)—induces immunostimulatory-shift of breast cancer
por: Zheng, Xunzhen, et al.
Publicado: (2020) -
Reduced S-nitrosylation of TGFβ1 elevates its binding affinity towards the receptor and promotes fibrogenic signaling in the breast
por: Letson, Joshua, et al.
Publicado: (2023) -
S-Nitrosylation: An Emerging Paradigm of Redox Signaling
por: Fernando, Veani, et al.
Publicado: (2019) -
Novel 3D Flipwell system that models gut mucosal microenvironment for studying interactions between gut microbiota, epithelia and immunity
por: Beamer, Maria A., et al.
Publicado: (2023)