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Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes

Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option...

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Autores principales: Hanieh, Patrizia N., Forte, Jacopo, Di Meo, Chiara, Ammendolia, Maria Grazia, Del Favero, Elena, Cantù, Laura, Rinaldi, Federica, Marianecci, Carlotta, Carafa, Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201220/
https://www.ncbi.nlm.nih.gov/pubmed/34198955
http://dx.doi.org/10.3390/molecules26113434
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author Hanieh, Patrizia N.
Forte, Jacopo
Di Meo, Chiara
Ammendolia, Maria Grazia
Del Favero, Elena
Cantù, Laura
Rinaldi, Federica
Marianecci, Carlotta
Carafa, Maria
author_facet Hanieh, Patrizia N.
Forte, Jacopo
Di Meo, Chiara
Ammendolia, Maria Grazia
Del Favero, Elena
Cantù, Laura
Rinaldi, Federica
Marianecci, Carlotta
Carafa, Maria
author_sort Hanieh, Patrizia N.
collection PubMed
description Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chemically modified to tailor its physico-chemical properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span(®) or Tween(®) niosomes providing them with an intrinsic targeting shell. The nanocarrier physico-chemical properties were analyzed in terms of hydrodynamic diameter, ζ-potential, and bilayer structural features to evaluate the difference between naked and HA-coated niosomes. Niosomes stability was evaluated over time and in bovine serum. Moreover, interaction properties of HA-coated nanovesicles with model membranes, namely liposomes, were studied, to obtain insights on their interaction behavior with biological membranes in future experiments. The obtained coated systems showed good chemical physical features and represent a good opportunity to carry out active targeting strategies.
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spelling pubmed-82012202021-06-15 Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes Hanieh, Patrizia N. Forte, Jacopo Di Meo, Chiara Ammendolia, Maria Grazia Del Favero, Elena Cantù, Laura Rinaldi, Federica Marianecci, Carlotta Carafa, Maria Molecules Article Hyaluronic acid (HA) is one of the most used biopolymers in the development of drug delivery systems, due to its biocompatibility, biodegradability, non-immunogenicity and intrinsic-targeting properties. HA specifically binds to CD44; this property combined to the EPR effect could provide an option for reinforced active tumor targeting by nanocarriers, improving drug uptake by the cancer cells via the HA-CD44 receptor-mediated endocytosis pathway. Moreover, HA can be easily chemically modified to tailor its physico-chemical properties in view of specific applications. The derivatization with cholesterol confers to HA an amphiphilic character, and then the ability of anchoring to niosomes. HA-Chol was then used to coat Span(®) or Tween(®) niosomes providing them with an intrinsic targeting shell. The nanocarrier physico-chemical properties were analyzed in terms of hydrodynamic diameter, ζ-potential, and bilayer structural features to evaluate the difference between naked and HA-coated niosomes. Niosomes stability was evaluated over time and in bovine serum. Moreover, interaction properties of HA-coated nanovesicles with model membranes, namely liposomes, were studied, to obtain insights on their interaction behavior with biological membranes in future experiments. The obtained coated systems showed good chemical physical features and represent a good opportunity to carry out active targeting strategies. MDPI 2021-06-05 /pmc/articles/PMC8201220/ /pubmed/34198955 http://dx.doi.org/10.3390/molecules26113434 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Hanieh, Patrizia N.
Forte, Jacopo
Di Meo, Chiara
Ammendolia, Maria Grazia
Del Favero, Elena
Cantù, Laura
Rinaldi, Federica
Marianecci, Carlotta
Carafa, Maria
Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
title Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
title_full Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
title_fullStr Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
title_full_unstemmed Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
title_short Hyaluronic Acid Derivative Effect on Niosomal Coating and Interaction with Cellular Mimetic Membranes
title_sort hyaluronic acid derivative effect on niosomal coating and interaction with cellular mimetic membranes
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201220/
https://www.ncbi.nlm.nih.gov/pubmed/34198955
http://dx.doi.org/10.3390/molecules26113434
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