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Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors
This work aimed to construct 3D-QSAR CoMFA and CoMSIA models for a series of 31 FAAH inhibitors, containing the 1,3,4-oxadiazol-2-one moiety. The obtained models were characterized by good statistical parameters: CoMFA Q(2) = 0.61, R(2) = 0.98; CoMSIA Q(2) = 0.64, R(2) = 0.93. The CoMFA model field...
Autores principales: | Zięba, Agata, Laitinen, Tuomo, Patel, Jayendra Z., Poso, Antti, Kaczor, Agnieszka A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201265/ https://www.ncbi.nlm.nih.gov/pubmed/34204026 http://dx.doi.org/10.3390/ijms22116108 |
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