Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar

Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was ful...

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Detalles Bibliográficos
Autores principales: Solofomalala, Anjaramampionona Henintsoa Duvale, Rajemiarimoelisoa, Clara Fredeline, Judicael, Randriamampianina Lovarintsoa, Randrianarivo, Hanitra Ranjana, Rakoto, Danielle Aurore Doll, Jeannoda, Victor Louis, Boumendjel, Ahcène
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201287/
https://www.ncbi.nlm.nih.gov/pubmed/34200328
http://dx.doi.org/10.3390/molecules26113464
Descripción
Sumario:Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of Crotalaria cleomifolia must be considered.

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