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Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar
Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was ful...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2021
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201287/ https://www.ncbi.nlm.nih.gov/pubmed/34200328 http://dx.doi.org/10.3390/molecules26113464 |
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| author | Solofomalala, Anjaramampionona Henintsoa Duvale Rajemiarimoelisoa, Clara Fredeline Judicael, Randriamampianina Lovarintsoa Randrianarivo, Hanitra Ranjana Rakoto, Danielle Aurore Doll Jeannoda, Victor Louis Boumendjel, Ahcène |
| author_facet | Solofomalala, Anjaramampionona Henintsoa Duvale Rajemiarimoelisoa, Clara Fredeline Judicael, Randriamampianina Lovarintsoa Randrianarivo, Hanitra Ranjana Rakoto, Danielle Aurore Doll Jeannoda, Victor Louis Boumendjel, Ahcène |
| author_sort | Solofomalala, Anjaramampionona Henintsoa Duvale |
| collection | PubMed |
| description | Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of Crotalaria cleomifolia must be considered. |
| format | Online Article Text |
| id | pubmed-8201287 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2021 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-82012872021-06-15 Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar Solofomalala, Anjaramampionona Henintsoa Duvale Rajemiarimoelisoa, Clara Fredeline Judicael, Randriamampianina Lovarintsoa Randrianarivo, Hanitra Ranjana Rakoto, Danielle Aurore Doll Jeannoda, Victor Louis Boumendjel, Ahcène Molecules Communication Seeds of Crotalaria cleomifolia (Fabaceae) are consumed in Madagascar in preparation of popular beverages. The investigation of extracts from the seeds of this species revealed the presence of high amounts of alkaloids from which two pyrrolizidine-derived alkaloids were isolated. One of them was fully characterized by spectroscopic and spectrometric methods, which was found to be usaramine. Owing to the high toxicity of these alkaloids, issuing a strong warning among populations consuming the seeds of Crotalaria cleomifolia must be considered. MDPI 2021-06-07 /pmc/articles/PMC8201287/ /pubmed/34200328 http://dx.doi.org/10.3390/molecules26113464 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Communication Solofomalala, Anjaramampionona Henintsoa Duvale Rajemiarimoelisoa, Clara Fredeline Judicael, Randriamampianina Lovarintsoa Randrianarivo, Hanitra Ranjana Rakoto, Danielle Aurore Doll Jeannoda, Victor Louis Boumendjel, Ahcène Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar |
| title | Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar |
| title_full | Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar |
| title_fullStr | Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar |
| title_full_unstemmed | Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar |
| title_short | Pyrrolizidine-Derived Alkaloids: Highly Toxic Components in the Seeds of Crotalaria cleomifolia Used in Popular Beverages in Madagascar |
| title_sort | pyrrolizidine-derived alkaloids: highly toxic components in the seeds of crotalaria cleomifolia used in popular beverages in madagascar |
| topic | Communication |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201287/ https://www.ncbi.nlm.nih.gov/pubmed/34200328 http://dx.doi.org/10.3390/molecules26113464 |
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