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Gut Serpinome: Emerging Evidence in IBD
Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue bet...
Autores principales: | , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201313/ https://www.ncbi.nlm.nih.gov/pubmed/34200095 http://dx.doi.org/10.3390/ijms22116088 |
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author | Mkaouar, Héla Mariaule, Vincent Rhimi, Soufien Hernandez, Juan Kriaa, Aicha Jablaoui, Amin Akermi, Nizar Maguin, Emmanuelle Lesner, Adam Korkmaz, Brice Rhimi, Moez |
author_facet | Mkaouar, Héla Mariaule, Vincent Rhimi, Soufien Hernandez, Juan Kriaa, Aicha Jablaoui, Amin Akermi, Nizar Maguin, Emmanuelle Lesner, Adam Korkmaz, Brice Rhimi, Moez |
author_sort | Mkaouar, Héla |
collection | PubMed |
description | Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue between the gut microbiota and the host remains poorly understood. Increased activity of serine proteases is demonstrated in IBD patients and may contribute to the onset and the maintenance of the disease. The intestinal proteolytic balance is the result of an equilibrium between the proteases and their corresponding inhibitors. Interestingly, the serine protease inhibitors (serpins) encoded by the host are well reported; in contrast, those from the gut microbiota remain poorly studied. In this review, we provide a concise analysis of the roles of serine protease in IBD physiopathology and we focus on the serpins from the gut microbiota (gut serpinome) and their relevance as a promising therapeutic approach. |
format | Online Article Text |
id | pubmed-8201313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-82013132021-06-15 Gut Serpinome: Emerging Evidence in IBD Mkaouar, Héla Mariaule, Vincent Rhimi, Soufien Hernandez, Juan Kriaa, Aicha Jablaoui, Amin Akermi, Nizar Maguin, Emmanuelle Lesner, Adam Korkmaz, Brice Rhimi, Moez Int J Mol Sci Review Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue between the gut microbiota and the host remains poorly understood. Increased activity of serine proteases is demonstrated in IBD patients and may contribute to the onset and the maintenance of the disease. The intestinal proteolytic balance is the result of an equilibrium between the proteases and their corresponding inhibitors. Interestingly, the serine protease inhibitors (serpins) encoded by the host are well reported; in contrast, those from the gut microbiota remain poorly studied. In this review, we provide a concise analysis of the roles of serine protease in IBD physiopathology and we focus on the serpins from the gut microbiota (gut serpinome) and their relevance as a promising therapeutic approach. MDPI 2021-06-04 /pmc/articles/PMC8201313/ /pubmed/34200095 http://dx.doi.org/10.3390/ijms22116088 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Mkaouar, Héla Mariaule, Vincent Rhimi, Soufien Hernandez, Juan Kriaa, Aicha Jablaoui, Amin Akermi, Nizar Maguin, Emmanuelle Lesner, Adam Korkmaz, Brice Rhimi, Moez Gut Serpinome: Emerging Evidence in IBD |
title | Gut Serpinome: Emerging Evidence in IBD |
title_full | Gut Serpinome: Emerging Evidence in IBD |
title_fullStr | Gut Serpinome: Emerging Evidence in IBD |
title_full_unstemmed | Gut Serpinome: Emerging Evidence in IBD |
title_short | Gut Serpinome: Emerging Evidence in IBD |
title_sort | gut serpinome: emerging evidence in ibd |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201313/ https://www.ncbi.nlm.nih.gov/pubmed/34200095 http://dx.doi.org/10.3390/ijms22116088 |
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