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Gut Serpinome: Emerging Evidence in IBD

Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue bet...

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Autores principales: Mkaouar, Héla, Mariaule, Vincent, Rhimi, Soufien, Hernandez, Juan, Kriaa, Aicha, Jablaoui, Amin, Akermi, Nizar, Maguin, Emmanuelle, Lesner, Adam, Korkmaz, Brice, Rhimi, Moez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201313/
https://www.ncbi.nlm.nih.gov/pubmed/34200095
http://dx.doi.org/10.3390/ijms22116088
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author Mkaouar, Héla
Mariaule, Vincent
Rhimi, Soufien
Hernandez, Juan
Kriaa, Aicha
Jablaoui, Amin
Akermi, Nizar
Maguin, Emmanuelle
Lesner, Adam
Korkmaz, Brice
Rhimi, Moez
author_facet Mkaouar, Héla
Mariaule, Vincent
Rhimi, Soufien
Hernandez, Juan
Kriaa, Aicha
Jablaoui, Amin
Akermi, Nizar
Maguin, Emmanuelle
Lesner, Adam
Korkmaz, Brice
Rhimi, Moez
author_sort Mkaouar, Héla
collection PubMed
description Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue between the gut microbiota and the host remains poorly understood. Increased activity of serine proteases is demonstrated in IBD patients and may contribute to the onset and the maintenance of the disease. The intestinal proteolytic balance is the result of an equilibrium between the proteases and their corresponding inhibitors. Interestingly, the serine protease inhibitors (serpins) encoded by the host are well reported; in contrast, those from the gut microbiota remain poorly studied. In this review, we provide a concise analysis of the roles of serine protease in IBD physiopathology and we focus on the serpins from the gut microbiota (gut serpinome) and their relevance as a promising therapeutic approach.
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spelling pubmed-82013132021-06-15 Gut Serpinome: Emerging Evidence in IBD Mkaouar, Héla Mariaule, Vincent Rhimi, Soufien Hernandez, Juan Kriaa, Aicha Jablaoui, Amin Akermi, Nizar Maguin, Emmanuelle Lesner, Adam Korkmaz, Brice Rhimi, Moez Int J Mol Sci Review Inflammatory bowel diseases (IBD) are incurable disorders whose prevalence and global socioeconomic impact are increasing. While the role of host genetics and immunity is well documented, that of gut microbiota dysbiosis is increasingly being studied. However, the molecular basis of the dialogue between the gut microbiota and the host remains poorly understood. Increased activity of serine proteases is demonstrated in IBD patients and may contribute to the onset and the maintenance of the disease. The intestinal proteolytic balance is the result of an equilibrium between the proteases and their corresponding inhibitors. Interestingly, the serine protease inhibitors (serpins) encoded by the host are well reported; in contrast, those from the gut microbiota remain poorly studied. In this review, we provide a concise analysis of the roles of serine protease in IBD physiopathology and we focus on the serpins from the gut microbiota (gut serpinome) and their relevance as a promising therapeutic approach. MDPI 2021-06-04 /pmc/articles/PMC8201313/ /pubmed/34200095 http://dx.doi.org/10.3390/ijms22116088 Text en © 2021 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Mkaouar, Héla
Mariaule, Vincent
Rhimi, Soufien
Hernandez, Juan
Kriaa, Aicha
Jablaoui, Amin
Akermi, Nizar
Maguin, Emmanuelle
Lesner, Adam
Korkmaz, Brice
Rhimi, Moez
Gut Serpinome: Emerging Evidence in IBD
title Gut Serpinome: Emerging Evidence in IBD
title_full Gut Serpinome: Emerging Evidence in IBD
title_fullStr Gut Serpinome: Emerging Evidence in IBD
title_full_unstemmed Gut Serpinome: Emerging Evidence in IBD
title_short Gut Serpinome: Emerging Evidence in IBD
title_sort gut serpinome: emerging evidence in ibd
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201313/
https://www.ncbi.nlm.nih.gov/pubmed/34200095
http://dx.doi.org/10.3390/ijms22116088
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