Cargando…

PRMT5 Selective Inhibitor Enhances Therapeutic Efficacy of Cisplatin in Lung Cancer Cells

As a therapeutic approach, epigenetic modifiers have the potential to enhance the efficacy of chemotherapeutic agents. Protein arginine methyltransferase 5 (PRMT5), highly expressed in lung adenocarcinoma, was identified to be involved in tumorigenesis. In the current study, we examined the potentia...

Descripción completa

Detalles Bibliográficos
Autores principales:	Bajbouj, Khuloud, Ramakrishnan, Rakhee K., Saber-Ayad, Maha, Omar, Hany A., Saheb Sharif-Askari, Narjes, Shafarin, Jasmin, Elmoselhi, Adel B., Ihmaid, Ahmed, AlHaj Ali, Suhib, Alalool, Abdulla, Abdullah, Reem, Hamid, Qutayba
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201369/ https://www.ncbi.nlm.nih.gov/pubmed/34200178 http://dx.doi.org/10.3390/ijms22116131

Ejemplares similares

Nucleic acid sensor STING drives remodeling and its inhibition enhances steroid responsiveness in chronic obstructive pulmonary disease
por: Mdkhana, Bushra, et al.
Publicado: (2023)

Histone Modification in NSCLC: Molecular Mechanisms and Therapeutic Targets
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

Role of Matrix Metalloproteinases in Angiogenesis and Its Implications in Asthma
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

IL-13 Augments Histone Demethylase JMJD2B/KDM4B Expression Levels, Activity, and Nuclear Translocation in Airway Fibroblasts in Asthma
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

Nucleic Acid-Sensing Pathways During SARS-CoV-2 Infection: Expectations versus Reality
por: Mdkhana, Bushra, et al.
Publicado: (2021)

Vitamin D Exerts Significant Antitumor Effects by Suppressing Vasculogenic Mimicry in Breast Cancer Cells
por: Bajbouj, Khuloud, et al.
Publicado: (2022)

High-Dose Deferoxamine Treatment Disrupts Intracellular Iron Homeostasis, Reduces Growth, and Induces Apoptosis in Metastatic and Nonmetastatic Breast Cancer Cell Lines
por: Bajbouj, Khuloud, et al.
Publicado: (2018)

Estrogen-dependent disruption of intracellular iron metabolism augments the cytotoxic effects of doxorubicin in select breast and ovarian cancer cells
por: Bajbouj, Khuloud, et al.
Publicado: (2019)

Estrogen Signaling Induces Mitochondrial Dysfunction-Associated Autophagy and Senescence in Breast Cancer Cells
por: Bajbouj, Khuloud, et al.
Publicado: (2020)

Association between body mass index and asthma severity in Arab pediatric population: A retrospective study
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2019)

Cardiovascular medications and regulation of COVID-19 receptors expression
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2020)

Airways Expression of SARS-CoV-2 Receptor, ACE2, and TMPRSS2 Is Lower in Children Than Adults and Increases with Smoking and COPD
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2020)

Early administration of remdesivir to COVID-19 patients associates with higher recovery rate and lower need for ICU admission: A retrospective cohort study
por: Hussain Alsayed, Hawra Ali, et al.
Publicado: (2021)

Enhanced Expression of Autoantigens During SARS-CoV-2 Viral Infection
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2021)

Enhanced expression of immune checkpoint receptors during SARS-CoV-2 viral infection
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2020)

SARS-CoV-2 attenuates corticosteroid sensitivity by suppressing DUSP1 expression and activating p38 MAPK pathway
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2021)

Airways tissue expression of type I interferons and their stimulated genes is higher in children than adults
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2022)

Iron Overload Induces Oxidative Stress, Cell Cycle Arrest and Apoptosis in Chondrocytes
por: Karim, Asima, et al.
Publicado: (2022)

Upregulation of oxidative stress gene markers during SARS-COV-2 viral infection
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2021)

Vitamin D enhances type I IFN signaling in COVID-19 patients
por: Hafezi, Shirin, et al.
Publicado: (2022)

Enhanced mitophagy in bronchial fibroblasts from severe asthmatic patients
por: Ramakrishnan, Rakhee K., et al.
Publicado: (2020)

Bcl10 Regulates Lipopolysaccharide-Induced Pro-Fibrotic Signaling in Bronchial Fibroblasts from Severe Asthma Patients
por: Ramakrishnan, Rakhee K., et al.
Publicado: (2022)

Continuous positive airway pressure therapy suppresses inflammatory cytokines and improves glucocorticoid responsiveness in patients with obstructive sleep apnea and asthma: A case–control study
por: Mahboub, Bassam, et al.
Publicado: (2022)

Effect of common medications on the expression of SARS-CoV-2 entry receptors in liver tissue
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2020)

Adverse drug reactions reported to the drug and poison information center of Tehran, Iran
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2017)

Luteolin inhibits proliferation, triggers apoptosis and modulates Akt/mTOR and MAP kinase pathways in HeLa cells
por: Raina, Ritu, et al.
Publicado: (2021)

SARS-CoV-2 Switches ‘on’ MAPK and NFκB Signaling via the Reduction of Nuclear DUSP1 and DUSP5 Expression
por: Goel, Swati, et al.
Publicado: (2021)

Fisetin Deters Cell Proliferation, Induces Apoptosis, Alleviates Oxidative Stress and Inflammation in Human Cancer Cells, HeLa
por: Afroze, Nazia, et al.
Publicado: (2022)

Upregulation of interleukin-19 in severe asthma: a potential saliva biomarker for asthma severity
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2021)

Wnt Signaling Is Deranged in Asthmatic Bronchial Epithelium and Fibroblasts
por: Hachim, Mahmood Yaseen, et al.
Publicado: (2021)

Blood Neutrophil-to-Lymphocyte Ratio and Urine IL-8 Levels Predict the Type of Bacterial Urinary Tract Infection in Type 2 Diabetes Mellitus Patients
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2020)

Development of an Adverse Drug Reaction Risk Assessment Score among Hospitalized Patients with Chronic Kidney Disease
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2014)

Low Vitamin D Serum Level Is Associated with HDL-C Dyslipidemia and Increased Serum Thrombomodulin Levels of Insulin-Resistant Individuals
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2020)

Azithromycin Differentially Alters TCR-Activated Helper T Cell Subset Phenotype and Effector Function
por: Ansari, Abdul Wahid, et al.
Publicado: (2020)

Upregulation of interleukin-19 in saliva of patients with COVID-19
por: Saheb Sharif-Askari, Fatemeh, et al.
Publicado: (2022)

Co-targeting BET bromodomain BRD4 and RAC1 suppresses growth, stemness and tumorigenesis by disrupting the c-MYC-G9a-FTH1axis and downregulating HDAC1 in molecular subtypes of breast cancer
por: Ali, Amjad, et al.
Publicado: (2021)

Vitamin D-Mediated Anti-cancer Activity Involves Iron Homeostatic Balance Disruption and Oxidative Stress Induction in Breast Cancer
por: Bajbouj, Khuloud, et al.
Publicado: (2021)

Incidence of bladder cancer in Benghazi, Libya over the past three decades
por: Saheb Sharif-Askari, Narjes, et al.
Publicado: (2018)

Prediabetes and diabetes prevalence and risk factors comparison between ethnic groups in the United Arab Emirates
por: Hamoudi, Rifat, et al.
Publicado: (2019)

Effect of Common Medications on the Expression of SARS‐CoV‐2 Entry Receptors in Kidney Tissue
por: Saheb Sharif‐Askari, Narjes, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_517nqoi2d6ll10uktvmq9vkeco