Trisubstituted Pyrrolinones as Small-Molecule Inhibitors Disrupting the Protein–RNA Interaction of LIN28 and Let-7

[Image: see text] Modulation of protein–RNA interaction (PRI) using small molecules is a promising strategy to develop therapeutics. LIN28 is an RNA-binding protein that blocks the maturation of the tumor suppressor let-7 microRNAs. Herein, we performed a fluorescence polarization-based screening an...

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Detalles Bibliográficos
Autores principales: Borgelt, Lydia, Li, Fu, Hommen, Pascal, Lampe, Philipp, Hwang, Jimin, Goebel, Georg L., Sievers, Sonja, Wu, Peng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2021
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201479/
https://www.ncbi.nlm.nih.gov/pubmed/34136077
http://dx.doi.org/10.1021/acsmedchemlett.0c00546

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