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Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol
BACKGROUND: Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association betwee...
Autores principales: | , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201673/ https://www.ncbi.nlm.nih.gov/pubmed/34127055 http://dx.doi.org/10.1186/s13643-021-01703-8 |
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author | Laflamme, Mathieu Haghbayan, Hourmazd Lalu, Manoj M. Zarychanski, Ryan Lauzier, François Boutin, Amélie Macleod, Malcolm R. Fergusson, Dean A. Moore, Lynne Costerousse, Olivier Lacroix, Jacques Wellington, Cheryl Hutchison, Jamie Turgeon, Alexis F. |
author_facet | Laflamme, Mathieu Haghbayan, Hourmazd Lalu, Manoj M. Zarychanski, Ryan Lauzier, François Boutin, Amélie Macleod, Malcolm R. Fergusson, Dean A. Moore, Lynne Costerousse, Olivier Lacroix, Jacques Wellington, Cheryl Hutchison, Jamie Turgeon, Alexis F. |
author_sort | Laflamme, Mathieu |
collection | PubMed |
description | BACKGROUND: Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models. METHODS: We will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE, and Web of Science databases for eligible studies from inception onwards. Two independent reviewers will perform study selection and data extraction. We will report our results in a descriptive synthesis focusing on characteristics of included studies, reported outcomes, risk of bias, and construct validity. Our primary outcome is the neurological function (neurobehavioral performance) and our secondary outcomes include mortality, infarct size, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and brain tissue oxygen tension. If appropriate, we will also perform a quantitative synthesis and pool results using random-effect models. Heterogeneity will be expressed with I(2) statistics. Subgroup analyses are planned according to animal model characteristics, co-interventions, and risks of bias. DISCUSSION: Our study is aligned with the efforts to better understand the level of evidence on the impact of red blood cell transfusion strategies from preclinical studies in animal models of acute brain injury and the potential translation of information from the preclinical to the clinical research field. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018086662. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01703-8. |
format | Online Article Text |
id | pubmed-8201673 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82016732021-06-15 Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol Laflamme, Mathieu Haghbayan, Hourmazd Lalu, Manoj M. Zarychanski, Ryan Lauzier, François Boutin, Amélie Macleod, Malcolm R. Fergusson, Dean A. Moore, Lynne Costerousse, Olivier Lacroix, Jacques Wellington, Cheryl Hutchison, Jamie Turgeon, Alexis F. Syst Rev Protocol BACKGROUND: Anemia is common in neurocritically ill patients. Considering the limited clinical evidence in this population, preclinical data may provide some understanding of the potential impact of anemia and of red blood cell transfusion in these patients. We aim to estimate the association between different transfusion strategies and neurobehavioral outcome in animal models. METHODS: We will conduct a systematic review of comparative studies of red blood cell transfusion strategies using animal models of traumatic brain injury, ischemic stroke or cerebral hemorrhage. We will search MEDLINE, EMBASE, and Web of Science databases for eligible studies from inception onwards. Two independent reviewers will perform study selection and data extraction. We will report our results in a descriptive synthesis focusing on characteristics of included studies, reported outcomes, risk of bias, and construct validity. Our primary outcome is the neurological function (neurobehavioral performance) and our secondary outcomes include mortality, infarct size, intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and brain tissue oxygen tension. If appropriate, we will also perform a quantitative synthesis and pool results using random-effect models. Heterogeneity will be expressed with I(2) statistics. Subgroup analyses are planned according to animal model characteristics, co-interventions, and risks of bias. DISCUSSION: Our study is aligned with the efforts to better understand the level of evidence on the impact of red blood cell transfusion strategies from preclinical studies in animal models of acute brain injury and the potential translation of information from the preclinical to the clinical research field. SYSTEMATIC REVIEW REGISTRATION: PROSPERO CRD42018086662. SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s13643-021-01703-8. BioMed Central 2021-06-14 /pmc/articles/PMC8201673/ /pubmed/34127055 http://dx.doi.org/10.1186/s13643-021-01703-8 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Protocol Laflamme, Mathieu Haghbayan, Hourmazd Lalu, Manoj M. Zarychanski, Ryan Lauzier, François Boutin, Amélie Macleod, Malcolm R. Fergusson, Dean A. Moore, Lynne Costerousse, Olivier Lacroix, Jacques Wellington, Cheryl Hutchison, Jamie Turgeon, Alexis F. Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
title | Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
title_full | Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
title_fullStr | Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
title_full_unstemmed | Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
title_short | Red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
title_sort | red blood cell transfusion in animal models of acute brain injuries: a systematic review protocol |
topic | Protocol |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201673/ https://www.ncbi.nlm.nih.gov/pubmed/34127055 http://dx.doi.org/10.1186/s13643-021-01703-8 |
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