Inhibition of ASIC1a-Mediated ERS Improves the Activation of HSCs and Copper Transport Under Copper Load

Hepatolenticular degeneration (HLD) is an autosomal recessive genetic disease caused by the toxic accumulation of copper in the liver. Excessive copper will disrupt the redox balance in cells and tissues, causing ischemia, hypoxia, and inflammation. Acid-sensitive ion channel 1a is a cationic channe...

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Detalles Bibliográficos
Autores principales: Kong, Lingjin, Huang, Huiping, Luan, Shaohua, Liu, Hui, Ye, Manping, Wu, Fanrong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201774/
https://www.ncbi.nlm.nih.gov/pubmed/34135753
http://dx.doi.org/10.3389/fphar.2021.653272

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201774/
https://www.ncbi.nlm.nih.gov/pubmed/34135753
http://dx.doi.org/10.3389/fphar.2021.653272

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