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Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria
BACKGROUND: Relapses in vivax malaria have posed great challenges for malaria control, and they also account for a great proportion of reported cases. Knowing the real effectiveness of a 7-day primaquine (PQ) scheme is crucial in order to evaluate not only the cost-effectiveness of implementing new...
Autores principales: | , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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BioMed Central
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201904/ https://www.ncbi.nlm.nih.gov/pubmed/34120622 http://dx.doi.org/10.1186/s12936-021-03793-0 |
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author | Dinelly, Kelry Mazurega Oliveira Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso |
author_facet | Dinelly, Kelry Mazurega Oliveira Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso |
author_sort | Dinelly, Kelry Mazurega Oliveira |
collection | PubMed |
description | BACKGROUND: Relapses in vivax malaria have posed great challenges for malaria control, and they also account for a great proportion of reported cases. Knowing the real effectiveness of a 7-day primaquine (PQ) scheme is crucial in order to evaluate not only the cost-effectiveness of implementing new anti-hypnozoite drugs, but also how health education strategies can guarantee better compliance and be reinforced. This study aimed to evaluate the effect of daily treatment with chloroquine and PQ supervised by health workers versus prescription without supervision. METHODS: The outcome was the passive detection of new positive thick blood smears up to 180 days, based on the official data records from the National Malaria Control Programme. The recurrences seen in the real life were, therefore, used as a surrogate for true relapses. RESULTS: Patients under supervised treatment had a lower risk of recurrence up to day 180 when compared to the unsupervised treatment (17.9% vs. 36.1%; p = 0.027). CONCLUSIONS: The lack of supervision in the non-supervised group (which followed standard of care in the real life) enabled proper comparison, as consent itself would have lead to greater compliance in this group. Future studies should scale such an analysis to different settings in the Brazilian Amazon. |
format | Online Article Text |
id | pubmed-8201904 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | BioMed Central |
record_format | MEDLINE/PubMed |
spelling | pubmed-82019042021-06-16 Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria Dinelly, Kelry Mazurega Oliveira Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso Malar J Research BACKGROUND: Relapses in vivax malaria have posed great challenges for malaria control, and they also account for a great proportion of reported cases. Knowing the real effectiveness of a 7-day primaquine (PQ) scheme is crucial in order to evaluate not only the cost-effectiveness of implementing new anti-hypnozoite drugs, but also how health education strategies can guarantee better compliance and be reinforced. This study aimed to evaluate the effect of daily treatment with chloroquine and PQ supervised by health workers versus prescription without supervision. METHODS: The outcome was the passive detection of new positive thick blood smears up to 180 days, based on the official data records from the National Malaria Control Programme. The recurrences seen in the real life were, therefore, used as a surrogate for true relapses. RESULTS: Patients under supervised treatment had a lower risk of recurrence up to day 180 when compared to the unsupervised treatment (17.9% vs. 36.1%; p = 0.027). CONCLUSIONS: The lack of supervision in the non-supervised group (which followed standard of care in the real life) enabled proper comparison, as consent itself would have lead to greater compliance in this group. Future studies should scale such an analysis to different settings in the Brazilian Amazon. BioMed Central 2021-06-13 /pmc/articles/PMC8201904/ /pubmed/34120622 http://dx.doi.org/10.1186/s12936-021-03793-0 Text en © The Author(s) 2021 https://creativecommons.org/licenses/by/4.0/Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) . The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/ (https://creativecommons.org/publicdomain/zero/1.0/) ) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
spellingShingle | Research Dinelly, Kelry Mazurega Oliveira Vitor-Silva, Sheila Brito-Sousa, Jose Diego Sampaio, Vanderson Souza Silva, Milena Gabriela Oliveira Siqueira, André Machado Peterka, Cássio Rodovalho, Sheila Omena, Aretha Gomes Monteiro, Wuelton Marcelo Lacerda, Marcus Vinícius Guimarães Melo, Gisely Cardoso Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
title | Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
title_full | Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
title_fullStr | Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
title_full_unstemmed | Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
title_short | Evaluation of the effect of supervised anti-malarial treatment on recurrences of Plasmodium vivax malaria |
title_sort | evaluation of the effect of supervised anti-malarial treatment on recurrences of plasmodium vivax malaria |
topic | Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8201904/ https://www.ncbi.nlm.nih.gov/pubmed/34120622 http://dx.doi.org/10.1186/s12936-021-03793-0 |
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