Extracellular Superoxide Dismutase (EC-SOD) Regulates Gene Methylation and Cardiac Fibrosis During Chronic Hypoxic Stress

Chronic hypoxic stress induces epigenetic modifications mainly DNA methylation in cardiac fibroblasts, inactivating tumor suppressor genes (RASSF1A) and activating kinases (ERK1/2) leading to fibroblast proliferation and cardiac fibrosis. The Ras/ERK signaling pathway is an intracellular signal tran...

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Detalles Bibliográficos
Autores principales: Rajgarhia, Ayan, Ayasolla, Kameshwar R., Zaghloul, Nahla, Lopez Da Re, Jorge M., Miller, Edmund J., Ahmed, Mohamed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2021
Materias:
Cardiovascular Medicine
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://www.ncbi.nlm.nih.gov/pubmed/34136546
http://dx.doi.org/10.3389/fcvm.2021.669975

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202000/
https://www.ncbi.nlm.nih.gov/pubmed/34136546
http://dx.doi.org/10.3389/fcvm.2021.669975

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