A systematic analysis of signaling reactivation and drug resistance

Increasing evidence suggests that the reactivation of initially inhibited signaling pathways causes drug resistance. Here, we analyze how network topologies affect signaling responses to drug treatment. Network-dependent drug resistance is commonly attributed to negative and positive feedback loops....

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Detalles Bibliográficos
Autores principales: Kholodenko, Boris N., Rauch, Nora, Kolch, Walter, Rukhlenko, Oleksii S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2021
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202068/
https://www.ncbi.nlm.nih.gov/pubmed/34038718
http://dx.doi.org/10.1016/j.celrep.2021.109157

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202068/
https://www.ncbi.nlm.nih.gov/pubmed/34038718
http://dx.doi.org/10.1016/j.celrep.2021.109157

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