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PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a m...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202228/ https://www.ncbi.nlm.nih.gov/pubmed/34151134 http://dx.doi.org/10.1007/s41666-021-00099-3 |
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author | Kamra, Nitin Zhang, Yizhou Rambhatla, Sirisha Meng, Chuizheng Liu, Yan |
author_facet | Kamra, Nitin Zhang, Yizhou Rambhatla, Sirisha Meng, Chuizheng Liu, Yan |
author_sort | Kamra, Nitin |
collection | PubMed |
description | Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a mathematical model, namely PolSIRD, which accounts for the under-reporting by introducing an observation mechanism. It also captures the effects of intervention policies on the disease spread parameters by leveraging intervention policy data along with the reported disease cases. Furthermore, we allow our recurrent model to learn the initial hidden state of all compartments end-to-end along with other parameters via gradient-based training. We apply our model to the spread of the recent global outbreak of COVID-19 in the USA, where our model outperforms the methods employed by the CDC in predicting the spread. We also provide counterfactual simulations from our model to analyze the effect of lifting the intervention policies prematurely and our model correctly predicts the second wave of the epidemic. |
format | Online Article Text |
id | pubmed-8202228 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-82022282021-06-15 PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA Kamra, Nitin Zhang, Yizhou Rambhatla, Sirisha Meng, Chuizheng Liu, Yan J Healthc Inform Res Research Article Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a mathematical model, namely PolSIRD, which accounts for the under-reporting by introducing an observation mechanism. It also captures the effects of intervention policies on the disease spread parameters by leveraging intervention policy data along with the reported disease cases. Furthermore, we allow our recurrent model to learn the initial hidden state of all compartments end-to-end along with other parameters via gradient-based training. We apply our model to the spread of the recent global outbreak of COVID-19 in the USA, where our model outperforms the methods employed by the CDC in predicting the spread. We also provide counterfactual simulations from our model to analyze the effect of lifting the intervention policies prematurely and our model correctly predicts the second wave of the epidemic. Springer International Publishing 2021-06-14 /pmc/articles/PMC8202228/ /pubmed/34151134 http://dx.doi.org/10.1007/s41666-021-00099-3 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021 |
spellingShingle | Research Article Kamra, Nitin Zhang, Yizhou Rambhatla, Sirisha Meng, Chuizheng Liu, Yan PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA |
title | PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA |
title_full | PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA |
title_fullStr | PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA |
title_full_unstemmed | PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA |
title_short | PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA |
title_sort | polsird: modeling epidemic spread under intervention policies: analyzing the first wave of covid-19 in the usa |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202228/ https://www.ncbi.nlm.nih.gov/pubmed/34151134 http://dx.doi.org/10.1007/s41666-021-00099-3 |
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