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PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA

Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a m...

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Autores principales: Kamra, Nitin, Zhang, Yizhou, Rambhatla, Sirisha, Meng, Chuizheng, Liu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202228/
https://www.ncbi.nlm.nih.gov/pubmed/34151134
http://dx.doi.org/10.1007/s41666-021-00099-3
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author Kamra, Nitin
Zhang, Yizhou
Rambhatla, Sirisha
Meng, Chuizheng
Liu, Yan
author_facet Kamra, Nitin
Zhang, Yizhou
Rambhatla, Sirisha
Meng, Chuizheng
Liu, Yan
author_sort Kamra, Nitin
collection PubMed
description Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a mathematical model, namely PolSIRD, which accounts for the under-reporting by introducing an observation mechanism. It also captures the effects of intervention policies on the disease spread parameters by leveraging intervention policy data along with the reported disease cases. Furthermore, we allow our recurrent model to learn the initial hidden state of all compartments end-to-end along with other parameters via gradient-based training. We apply our model to the spread of the recent global outbreak of COVID-19 in the USA, where our model outperforms the methods employed by the CDC in predicting the spread. We also provide counterfactual simulations from our model to analyze the effect of lifting the intervention policies prematurely and our model correctly predicts the second wave of the epidemic.
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spelling pubmed-82022282021-06-15 PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA Kamra, Nitin Zhang, Yizhou Rambhatla, Sirisha Meng, Chuizheng Liu, Yan J Healthc Inform Res Research Article Epidemic spread in a population is traditionally modeled via compartmentalized models which represent the free evolution of disease in the absence of any intervention policies. In addition, these models assume full observability of disease cases and do not account for under-reporting. We present a mathematical model, namely PolSIRD, which accounts for the under-reporting by introducing an observation mechanism. It also captures the effects of intervention policies on the disease spread parameters by leveraging intervention policy data along with the reported disease cases. Furthermore, we allow our recurrent model to learn the initial hidden state of all compartments end-to-end along with other parameters via gradient-based training. We apply our model to the spread of the recent global outbreak of COVID-19 in the USA, where our model outperforms the methods employed by the CDC in predicting the spread. We also provide counterfactual simulations from our model to analyze the effect of lifting the intervention policies prematurely and our model correctly predicts the second wave of the epidemic. Springer International Publishing 2021-06-14 /pmc/articles/PMC8202228/ /pubmed/34151134 http://dx.doi.org/10.1007/s41666-021-00099-3 Text en © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2021
spellingShingle Research Article
Kamra, Nitin
Zhang, Yizhou
Rambhatla, Sirisha
Meng, Chuizheng
Liu, Yan
PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
title PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
title_full PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
title_fullStr PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
title_full_unstemmed PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
title_short PolSIRD: Modeling Epidemic Spread Under Intervention Policies: Analyzing the First Wave of COVID-19 in the USA
title_sort polsird: modeling epidemic spread under intervention policies: analyzing the first wave of covid-19 in the usa
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202228/
https://www.ncbi.nlm.nih.gov/pubmed/34151134
http://dx.doi.org/10.1007/s41666-021-00099-3
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