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The local regulation of folliculogenesis by members of the transforming growth factor superfamily and its relevance for advanced breeding programmes
Regulation of the growth and maturation of the ovarian follicle is critical for normal reproductive function. Alterations in this growth can lead to pathological conditions, such as cystic follicles, reduced oocyte quality, or an abnormal endocrine environment leading to poor fertility. Alterations...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Colégio Brasileiro de Reprodução Animal
2018
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202455/ https://www.ncbi.nlm.nih.gov/pubmed/34178140 http://dx.doi.org/10.21451/1984-3143-AR2018-0055 |
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author | Juengel, Jennifer L. Smith, Peter R. Quirke, Laurel D. French, Michelle C. Edwards, Sara J. |
author_facet | Juengel, Jennifer L. Smith, Peter R. Quirke, Laurel D. French, Michelle C. Edwards, Sara J. |
author_sort | Juengel, Jennifer L. |
collection | PubMed |
description | Regulation of the growth and maturation of the ovarian follicle is critical for normal reproductive function. Alterations in this growth can lead to pathological conditions, such as cystic follicles, reduced oocyte quality, or an abnormal endocrine environment leading to poor fertility. Alterations in follicular growth also influence the number of follicles ovulating and thus can change litter size. Both endocrine factors, such as follicle stimulating hormone and luteinizing hormone, as well as local factors, are known to regulate follicular growth and development. This review will focus on the role of local factors in regulation of ovarian follicular growth in ruminants, with a focus on members of the transforming growth factor superfamily. The potential role of these factors in regulating proliferation, apoptosis, steroidogenesis and responsiveness to gonadotrophins will be considered. |
format | Online Article Text |
id | pubmed-8202455 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2018 |
publisher | Colégio Brasileiro de Reprodução Animal |
record_format | MEDLINE/PubMed |
spelling | pubmed-82024552021-06-25 The local regulation of folliculogenesis by members of the transforming growth factor superfamily and its relevance for advanced breeding programmes Juengel, Jennifer L. Smith, Peter R. Quirke, Laurel D. French, Michelle C. Edwards, Sara J. Anim Reprod Conference Papers Regulation of the growth and maturation of the ovarian follicle is critical for normal reproductive function. Alterations in this growth can lead to pathological conditions, such as cystic follicles, reduced oocyte quality, or an abnormal endocrine environment leading to poor fertility. Alterations in follicular growth also influence the number of follicles ovulating and thus can change litter size. Both endocrine factors, such as follicle stimulating hormone and luteinizing hormone, as well as local factors, are known to regulate follicular growth and development. This review will focus on the role of local factors in regulation of ovarian follicular growth in ruminants, with a focus on members of the transforming growth factor superfamily. The potential role of these factors in regulating proliferation, apoptosis, steroidogenesis and responsiveness to gonadotrophins will be considered. Colégio Brasileiro de Reprodução Animal 2018-08-16 /pmc/articles/PMC8202455/ /pubmed/34178140 http://dx.doi.org/10.21451/1984-3143-AR2018-0055 Text en https://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Conference Papers Juengel, Jennifer L. Smith, Peter R. Quirke, Laurel D. French, Michelle C. Edwards, Sara J. The local regulation of folliculogenesis by members of the transforming growth factor superfamily and its relevance for advanced breeding programmes |
title |
The local regulation of folliculogenesis by members of the transforming growth factor superfamily
and its relevance for advanced breeding programmes
|
title_full |
The local regulation of folliculogenesis by members of the transforming growth factor superfamily
and its relevance for advanced breeding programmes
|
title_fullStr |
The local regulation of folliculogenesis by members of the transforming growth factor superfamily
and its relevance for advanced breeding programmes
|
title_full_unstemmed |
The local regulation of folliculogenesis by members of the transforming growth factor superfamily
and its relevance for advanced breeding programmes
|
title_short |
The local regulation of folliculogenesis by members of the transforming growth factor superfamily
and its relevance for advanced breeding programmes
|
title_sort | local regulation of folliculogenesis by members of the transforming growth factor superfamily
and its relevance for advanced breeding programmes |
topic | Conference Papers |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202455/ https://www.ncbi.nlm.nih.gov/pubmed/34178140 http://dx.doi.org/10.21451/1984-3143-AR2018-0055 |
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