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Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration
RATIONALE: Laser induced maculopathy includes retinal photoreceptor disruption, macular hole, macular hemorrhage, and rarely choroidal neovascularization (CNV). Here we report a case of laser induced CNV that was treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and re...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Lippincott Williams & Wilkins
2021
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202587/ https://www.ncbi.nlm.nih.gov/pubmed/34115011 http://dx.doi.org/10.1097/MD.0000000000026239 |
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author | Li, Caixin Li, Jianqing Chen, Xinzhu Lu, Peirong |
author_facet | Li, Caixin Li, Jianqing Chen, Xinzhu Lu, Peirong |
author_sort | Li, Caixin |
collection | PubMed |
description | RATIONALE: Laser induced maculopathy includes retinal photoreceptor disruption, macular hole, macular hemorrhage, and rarely choroidal neovascularization (CNV). Here we report a case of laser induced CNV that was treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and resulted in visual improvement and CNV resolution during 1-year follow up. In addition, the case of laser induced CNV treated with intravitreal anti-VEGF injections are reviewed for the first time in literature. PATIENT CONCERNS: A 7-year-old boy presented to our department with blurred vision in his right eye for 2 months. The symptom immediately happened after the boy staring at the laser beam for a few seconds. Examination of ocular fundus with slit lamp showed yellowish lesion in macula in his right eye. DIAGNOSES: CNV was confirmed by fundus examinations, including color fundus photograph, spectral domain optical coherence tomography, fluorescein angiography, and spectral domain optical coherence tomography angiography. INTERVENTIONS: After the diagnosis of laser induced CNV, intravitreal ranibizumab (LUCENTIS, NOVARTIS) injection was performed. OUTCOMES: After 1 injection of intravitreal ranibizumab, the best corrected visual acuity improved from 20/50 to 30/50 and CNV gradually regressed during 1-year follow up. LESSONS: For young patients with laser induced CNV, intravitreal anti-VEGF injections may be helpful in visual improvement and CNV regression. Moreover, age seems to be a significant factor thus we propose that old animals may be more appropriate for laser induced CNV animal models of age-related macular degeneration. |
format | Online Article Text |
id | pubmed-8202587 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2021 |
publisher | Lippincott Williams & Wilkins |
record_format | MEDLINE/PubMed |
spelling | pubmed-82025872021-06-15 Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration Li, Caixin Li, Jianqing Chen, Xinzhu Lu, Peirong Medicine (Baltimore) 5800 RATIONALE: Laser induced maculopathy includes retinal photoreceptor disruption, macular hole, macular hemorrhage, and rarely choroidal neovascularization (CNV). Here we report a case of laser induced CNV that was treated by intravitreal anti-vascular endothelial growth factor (VEGF) injection and resulted in visual improvement and CNV resolution during 1-year follow up. In addition, the case of laser induced CNV treated with intravitreal anti-VEGF injections are reviewed for the first time in literature. PATIENT CONCERNS: A 7-year-old boy presented to our department with blurred vision in his right eye for 2 months. The symptom immediately happened after the boy staring at the laser beam for a few seconds. Examination of ocular fundus with slit lamp showed yellowish lesion in macula in his right eye. DIAGNOSES: CNV was confirmed by fundus examinations, including color fundus photograph, spectral domain optical coherence tomography, fluorescein angiography, and spectral domain optical coherence tomography angiography. INTERVENTIONS: After the diagnosis of laser induced CNV, intravitreal ranibizumab (LUCENTIS, NOVARTIS) injection was performed. OUTCOMES: After 1 injection of intravitreal ranibizumab, the best corrected visual acuity improved from 20/50 to 30/50 and CNV gradually regressed during 1-year follow up. LESSONS: For young patients with laser induced CNV, intravitreal anti-VEGF injections may be helpful in visual improvement and CNV regression. Moreover, age seems to be a significant factor thus we propose that old animals may be more appropriate for laser induced CNV animal models of age-related macular degeneration. Lippincott Williams & Wilkins 2021-06-11 /pmc/articles/PMC8202587/ /pubmed/34115011 http://dx.doi.org/10.1097/MD.0000000000026239 Text en Copyright © 2021 the Author(s). Published by Wolters Kluwer Health, Inc. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License 4.0 (CCBY), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 (https://creativecommons.org/licenses/by/4.0/) |
spellingShingle | 5800 Li, Caixin Li, Jianqing Chen, Xinzhu Lu, Peirong Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration |
title | Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration |
title_full | Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration |
title_fullStr | Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration |
title_full_unstemmed | Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration |
title_short | Laser-induced choroidal neovascularization: A case report and some reflection on animal models for age-related macular degeneration |
title_sort | laser-induced choroidal neovascularization: a case report and some reflection on animal models for age-related macular degeneration |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202587/ https://www.ncbi.nlm.nih.gov/pubmed/34115011 http://dx.doi.org/10.1097/MD.0000000000026239 |
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