Cargando…

Safety and Efficacy of a Typhoid Conjugate Vaccine in Malawian Children

BACKGROUND: Typhoid fever caused by multidrug-resistant H58 Salmonella Typhi is an increasing public-health threat in sub-Saharan Africa. We present phase 3 efficacy data from an African trial of a Vi-polysaccharide typhoid conjugate vaccine (Vi-TCV). METHODS: Children aged 9 months to 12 years in B...

Descripción completa

Detalles Bibliográficos
Autores principales:	Patel, Priyanka D., Patel, Pratiksha, Liang, Yuanyuan, Meiring, James E., Misiri, Theresa, Mwakiseghile, Felistas, Tracy, J. Kathleen, Masesa, Clemens, Msuku, Harrison, Banda, David, Mbewe, Maurice, Henrion, Marc, Adetunji, Fiyinfolu, Simiyu, Kenneth, Rotrosen, Elizabeth, Birkhold, Megan, Nampota, Nginache, Nyirenda, Osward M., Kotloff, Karen, Gmeiner, Markus, Dube, Queen, Kawalazira, Gift, Laurens, Matthew B., Heyderman, Robert S., Gordon, Melita A., Neuzil, Kathleen M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Massachusetts Medical Society 2021
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202713/ https://www.ncbi.nlm.nih.gov/pubmed/34525285 http://dx.doi.org/10.1056/NEJMoa2035916

Ejemplares similares

Typhoid Vaccine Acceleration Consortium Malawi: A Phase III, Randomized, Double-blind, Controlled Trial of the Clinical Efficacy of Typhoid Conjugate Vaccine Among Children in Blantyre, Malawi
por: Meiring, James E, et al.
Publicado: (2019)

Safety and immunogenicity of a typhoid conjugate vaccine among children aged 9 months to 12 years in Malawi: a nested substudy of a double-blind, randomised controlled trial
por: Nampota-Nkomba, Nginache, et al.
Publicado: (2022)

On the Ground in Malawi—First Typhoid Conjugate Vaccine Study in Africa
por: Patel, Pratiksha, et al.
Publicado: (2019)

Using Typhoid Conjugate Vaccines to Prevent Disease, Promote Health Equity, and Counter Drug-Resistant Typhoid Fever
por: Nampota-Nkomba, Nginache, et al.
Publicado: (2023)

Community Engagement Before Initiation of Typhoid Conjugate Vaccine Trial in Schools in Two Urban Townships in Blantyre, Malawi: Experience and Lessons
por: Meiring, James E, et al.
Publicado: (2019)

Isoniazid preventive therapy-related adverse events among Malawian adults on antiretroviral therapy: A cohort study
por: Tsirizani-Galileya, Lufina, et al.
Publicado: (2022)

Different clinical features in Malawian outpatients presenting with COVID-19 prior to and during Omicron variant dominance: A prospective observational study
por: Chibwana, Marah G., et al.
Publicado: (2023)

Cancer-work management: Hourly and salaried wage women’s experiences managing the cancer-work interface following new breast cancer diagnosis
por: Tracy, J. Kathleen, et al.
Publicado: (2020)

Typhoid Conjugate Vaccines: Advancing the Research and Public Health Agendas
por: Birkhold, Megan, et al.
Publicado: (2021)

Evaluating for Differences by Race/Ethnicity in the Association Between Income and Gambling Disorder
por: Day, Brendan, et al.
Publicado: (2020)

Managing the cancer–work interface: the effect of cancer survivorship on unemployment
por: Tracy, J Kathleen, et al.
Publicado: (2018)

Compensation of subjects for participation in biomedical research in resource – limited settings: a discussion of practices in Malawi
por: Nyangulu, Wongani, et al.
Publicado: (2019)

A Phase II, Randomized, Double-blind, Controlled Safety and Immunogenicity Trial of Typhoid Conjugate Vaccine in Children Under 2 Years of Age in Ouagadougou, Burkina Faso: A Methods Paper
por: Laurens, Matthew B, et al.
Publicado: (2019)

Morbidity and Mortality of Typhoid Intestinal Perforation Among Children in Sub-Saharan Africa 1995–2019: A Scoping Review
por: Birkhold, Megan, et al.
Publicado: (2020)

Sequential Acquisition of T Cells and Antibodies to Nontyphoidal Salmonella in Malawian Children
por: Nyirenda, Tonney S., et al.
Publicado: (2014)

Regulation of Naturally Acquired Mucosal Immunity to Streptococcus pneumoniae in Healthy Malawian Adults and Children
por: Glennie, Sarah J., et al.
Publicado: (2012)

Comparison of real-time PCR and microscopy for malaria parasite detection in Malawian pregnant women
por: Rantala, Anne-Maria, et al.
Publicado: (2010)

837 Early Goal Directed Therapy for Acute Bacterial Meningitis in Malawian Adults
por: Wall, Emma, et al.
Publicado: (2014)

The economic impact of childhood acute gastroenteritis on Malawian families and the healthcare system
por: Hendrix, Nathaniel, et al.
Publicado: (2017)

Hepatitis B Vaccination Impact and the Unmet Need for Antiviral Treatment in Blantyre, Malawi( )
por: Stockdale, Alexander J, et al.
Publicado: (2021)

Influenza-like illness is associated with high pneumococcal carriage density in Malawian children
por: Nyazika, Tinashe K., et al.
Publicado: (2020)

Delayed reconstitution of B cell immunity to pneumococcus in HIV-infected Malawian children on antiretroviral therapy
por: Iwajomo, Oluwadamilola H., et al.
Publicado: (2015)

Artemether-lumefantrine efficacy among adults on antiretroviral therapy in Malawi
por: Nyangulu, Wongani, et al.
Publicado: (2023)

HIV coinfection influences the inflammatory response but not the outcome of cerebral malaria in Malawian children
por: Mbale, Emmie W., et al.
Publicado: (2016)

Typhoid conjugate vaccine effectiveness in Malawi: evaluation of a test-negative design using randomised, controlled clinical trial data
por: Liang, Yuanyuan, et al.
Publicado: (2022)

Persistent Endothelial Activation and Inflammation After Plasmodium falciparum Infection in Malawian Children
por: Moxon, Christopher A., et al.
Publicado: (2014)

Chronic Household Air Pollution Exposure Is Associated with Impaired Alveolar Macrophage Function in Malawian Non-Smokers
por: Rylance, Jamie, et al.
Publicado: (2015)

Impairment of Pneumococcal Antigen Specific Isotype-Switched Igg Memory B-Cell Immunity in HIV Infected Malawian Adults
por: Iwajomo, Oluwadamilola H., et al.
Publicado: (2013)

Long-term effects of severe acute malnutrition on lung function in Malawian children: a cohort study
por: Lelijveld, Natasha, et al.
Publicado: (2017)

The role of angiogenic factors in predicting clinical outcome in severe bacterial infection in Malawian children
por: Mankhambo, Limangeni A, et al.
Publicado: (2010)

SARS-CoV-2 exposure in Malawian blood donors: an analysis of seroprevalence and variant dynamics between January 2020 and July 2021
por: Mandolo, Jonathan, et al.
Publicado: (2021)

HIV, antiretroviral treatment, hypertension, and stroke in Malawian adults: A case-control study
por: Benjamin, Laura A., et al.
Publicado: (2016)

Association of Human Leukocyte Antigen Alleles and Nevirapine Hypersensitivity in a Malawian HIV-Infected Population
por: Carr, Daniel F., et al.
Publicado: (2013)

Bacterial Meningitis in Malawian Infants <2 Months of Age: Etiology and Susceptibility to World Health Organization First-Line Antibiotics
por: Swann, Olivia, et al.
Publicado: (2014)

High multiple carriage and emergence of Streptococcus pneumoniae vaccine serotype variants in Malawian children
por: Kamng’ona, Arox W., et al.
Publicado: (2015)

The Diagnostic and Prognostic Accuracy of Five Markers of Serious Bacterial Infection in Malawian Children with Signs of Severe Infection
por: Carrol, Enitan D., et al.
Publicado: (2009)

Chronic disease outcomes after severe acute malnutrition in Malawian children (ChroSAM): a cohort study
por: Lelijveld, Natasha, et al.
Publicado: (2016)

Longitudinal lactate levels from routine point-of-care monitoring in adult Malawian antiretroviral therapy patients: associations with stavudine toxicities
por: Chagoma, Newton, et al.
Publicado: (2013)

Iodine source apportionment in the Malawian diet
por: Watts, M. J., et al.
Publicado: (2015)

Epstein-Barr Virus Coinfection in Cerebrospinal Fluid Is Associated With Increased Mortality in Malawian Adults With Bacterial Meningitis
por: Kelly, Matthew J., et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_3k91egi9hnonthime2bprr0dff