Cargando…

MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease

Alzheimer’s Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine learning derived biomarker that was developed to reflect the characteristic brain atrophy associated with AD. Recent study showed that AD-RAI (≥0.5) had the best performance in predicting conversion from mild cognitive im...

Descripción completa

Detalles Bibliográficos
Autores principales: Liu, Wanting, Au, Lisa Wing Chi, Abrigo, Jill, Luo, Yishan, Wong, Adrian, Lam, Bonnie Yin Ka, Fan, Xiang, Kwan, Pauline Wing Lam, Ma, Hon Wing, Ng, Anthea Yee Tung, Chen, Sirong, Leung, Eric Yim Lung, Ho, Chi Lai, Wong, Simon Ho Man, Chu, Winnie CW, Ko, Ho, Lau, Alexander Yuk Lun, Shi, Lin, Mok, Vincent Chung Tong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202853/
https://www.ncbi.nlm.nih.gov/pubmed/34091443
http://dx.doi.org/10.18632/aging.203082
_version_ 1783708048028598272
author Liu, Wanting
Au, Lisa Wing Chi
Abrigo, Jill
Luo, Yishan
Wong, Adrian
Lam, Bonnie Yin Ka
Fan, Xiang
Kwan, Pauline Wing Lam
Ma, Hon Wing
Ng, Anthea Yee Tung
Chen, Sirong
Leung, Eric Yim Lung
Ho, Chi Lai
Wong, Simon Ho Man
Chu, Winnie CW
Ko, Ho
Lau, Alexander Yuk Lun
Shi, Lin
Mok, Vincent Chung Tong
author_facet Liu, Wanting
Au, Lisa Wing Chi
Abrigo, Jill
Luo, Yishan
Wong, Adrian
Lam, Bonnie Yin Ka
Fan, Xiang
Kwan, Pauline Wing Lam
Ma, Hon Wing
Ng, Anthea Yee Tung
Chen, Sirong
Leung, Eric Yim Lung
Ho, Chi Lai
Wong, Simon Ho Man
Chu, Winnie CW
Ko, Ho
Lau, Alexander Yuk Lun
Shi, Lin
Mok, Vincent Chung Tong
author_sort Liu, Wanting
collection PubMed
description Alzheimer’s Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine learning derived biomarker that was developed to reflect the characteristic brain atrophy associated with AD. Recent study showed that AD-RAI (≥0.5) had the best performance in predicting conversion from mild cognitive impairment (MCI) to dementia and from cognitively unimpaired (CU) to MCI. We aimed to validate the performance of AD-RAI in detecting preclinical and prodromal AD. We recruited 128 subjects (MCI=50, CU=78) from two cohorts: CU-SEEDS and ADNI. Amyloid (A+) and tau (T+) status were confirmed by PET ((11)C-PIB, (18)F-T807) or CSF analysis. We investigated the performance of AD-RAI in detecting preclinical and prodromal AD (i.e. A+T+) among MCI and CU subjects and compared its performance with that of hippocampal measures. AD-RAI achieved the best metrics among all subjects (sensitivity 0.74, specificity 0.91, accuracy 85.94%) and among MCI subjects (sensitivity 0.92, specificity 0.81, accuracy 86.00%) in detecting A+T+ subjects over other measures. Among CU subjects, AD-RAI yielded the best specificity (0.95) and accuracy (85.90%) over other measures, while hippocampal volume achieved a higher sensitivity (0.73) than AD-RAI (0.47) in detecting preclinical AD. These results showed the potential of AD-RAI in the detection of early AD, in particular at the prodromal stage.
format Online
Article
Text
id pubmed-8202853
institution National Center for Biotechnology Information
language English
publishDate 2021
publisher Impact Journals
record_format MEDLINE/PubMed
spelling pubmed-82028532021-06-15 MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease Liu, Wanting Au, Lisa Wing Chi Abrigo, Jill Luo, Yishan Wong, Adrian Lam, Bonnie Yin Ka Fan, Xiang Kwan, Pauline Wing Lam Ma, Hon Wing Ng, Anthea Yee Tung Chen, Sirong Leung, Eric Yim Lung Ho, Chi Lai Wong, Simon Ho Man Chu, Winnie CW Ko, Ho Lau, Alexander Yuk Lun Shi, Lin Mok, Vincent Chung Tong Aging (Albany NY) Research Paper Alzheimer’s Disease-resemblance atrophy index (AD-RAI) is an MRI-based machine learning derived biomarker that was developed to reflect the characteristic brain atrophy associated with AD. Recent study showed that AD-RAI (≥0.5) had the best performance in predicting conversion from mild cognitive impairment (MCI) to dementia and from cognitively unimpaired (CU) to MCI. We aimed to validate the performance of AD-RAI in detecting preclinical and prodromal AD. We recruited 128 subjects (MCI=50, CU=78) from two cohorts: CU-SEEDS and ADNI. Amyloid (A+) and tau (T+) status were confirmed by PET ((11)C-PIB, (18)F-T807) or CSF analysis. We investigated the performance of AD-RAI in detecting preclinical and prodromal AD (i.e. A+T+) among MCI and CU subjects and compared its performance with that of hippocampal measures. AD-RAI achieved the best metrics among all subjects (sensitivity 0.74, specificity 0.91, accuracy 85.94%) and among MCI subjects (sensitivity 0.92, specificity 0.81, accuracy 86.00%) in detecting A+T+ subjects over other measures. Among CU subjects, AD-RAI yielded the best specificity (0.95) and accuracy (85.90%) over other measures, while hippocampal volume achieved a higher sensitivity (0.73) than AD-RAI (0.47) in detecting preclinical AD. These results showed the potential of AD-RAI in the detection of early AD, in particular at the prodromal stage. Impact Journals 2021-05-25 /pmc/articles/PMC8202853/ /pubmed/34091443 http://dx.doi.org/10.18632/aging.203082 Text en Copyright: © 2021 Liu et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Liu, Wanting
Au, Lisa Wing Chi
Abrigo, Jill
Luo, Yishan
Wong, Adrian
Lam, Bonnie Yin Ka
Fan, Xiang
Kwan, Pauline Wing Lam
Ma, Hon Wing
Ng, Anthea Yee Tung
Chen, Sirong
Leung, Eric Yim Lung
Ho, Chi Lai
Wong, Simon Ho Man
Chu, Winnie CW
Ko, Ho
Lau, Alexander Yuk Lun
Shi, Lin
Mok, Vincent Chung Tong
MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
title MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
title_full MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
title_fullStr MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
title_full_unstemmed MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
title_short MRI-based Alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal Alzheimer’s disease
title_sort mri-based alzheimer’s disease-resemblance atrophy index in the detection of preclinical and prodromal alzheimer’s disease
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202853/
https://www.ncbi.nlm.nih.gov/pubmed/34091443
http://dx.doi.org/10.18632/aging.203082
work_keys_str_mv AT liuwanting mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT aulisawingchi mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT abrigojill mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT luoyishan mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT wongadrian mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT lambonnieyinka mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT fanxiang mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT kwanpaulinewinglam mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT mahonwing mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT ngantheayeetung mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT chensirong mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT leungericyimlung mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT hochilai mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT wongsimonhoman mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT chuwinniecw mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT koho mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT laualexanderyuklun mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT shilin mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT mokvincentchungtong mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease
AT mribasedalzheimersdiseaseresemblanceatrophyindexinthedetectionofpreclinicalandprodromalalzheimersdisease