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Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts

The cause of cognitive dedifferentiation has been suggested as specific to late-life abnormal cognitive decline rather than a general feature of aging. This hypothesis was tested in two large cohorts with different characteristics. Individuals (n = 2710) were identified in the Alzheimer’s Disease Ne...

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Autores principales: Wallert, John, Rennie, Anna, Ferreira, Daniel, Muehlboeck, J-Sebastian, Wahlund, Lars-Olof, Westman, Eric, Ekman, Urban
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2021
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202862/
https://www.ncbi.nlm.nih.gov/pubmed/34038387
http://dx.doi.org/10.18632/aging.203108
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author Wallert, John
Rennie, Anna
Ferreira, Daniel
Muehlboeck, J-Sebastian
Wahlund, Lars-Olof
Westman, Eric
Ekman, Urban
author_facet Wallert, John
Rennie, Anna
Ferreira, Daniel
Muehlboeck, J-Sebastian
Wahlund, Lars-Olof
Westman, Eric
Ekman, Urban
author_sort Wallert, John
collection PubMed
description The cause of cognitive dedifferentiation has been suggested as specific to late-life abnormal cognitive decline rather than a general feature of aging. This hypothesis was tested in two large cohorts with different characteristics. Individuals (n = 2710) were identified in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) research database (n = 1282) in North America, and in the naturalistic multi-site MemClin Project database (n = 1223), the latter recruiting from 9 out of 10 memory clinics in the greater Stockholm catchment area in Sweden. Comprehensive neuropsychological testing informed diagnosis of dementia, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI). Diagnosis was further collapsed into cognitive impairment (CI: MCI or dementia) vs no cognitive impairment (NCI). After matching, loadings on the first principal component were higher in the CI vs NCI group in both ADNI (53.1% versus 38.3%) and MemClin (33.3% vs 30.8%). Correlations of all paired combinations of individual tests by diagnostic group were also stronger in the CI group in both ADNI (mean inter-test r = 0.51 vs r = 0.33, p < 0.001) and MemClin (r = 0.31 vs r = 0.27, p = 0.042). Dedifferentiation was explained by cognitive impairment when controlling for age, sex, and education. This finding replicated across two separate, large cohorts of older individuals. Knowledge that the structure of human cognition becomes less diversified and more dependent on general intelligence as a function of cognitive impairment should inform clinical assessment and care for these patients as their neurodegeneration progresses.
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spelling pubmed-82028622021-06-15 Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts Wallert, John Rennie, Anna Ferreira, Daniel Muehlboeck, J-Sebastian Wahlund, Lars-Olof Westman, Eric Ekman, Urban Aging (Albany NY) Research Paper The cause of cognitive dedifferentiation has been suggested as specific to late-life abnormal cognitive decline rather than a general feature of aging. This hypothesis was tested in two large cohorts with different characteristics. Individuals (n = 2710) were identified in the Alzheimer’s Disease Neuroimaging Initiative (ADNI) research database (n = 1282) in North America, and in the naturalistic multi-site MemClin Project database (n = 1223), the latter recruiting from 9 out of 10 memory clinics in the greater Stockholm catchment area in Sweden. Comprehensive neuropsychological testing informed diagnosis of dementia, mild cognitive impairment (MCI), or subjective cognitive impairment (SCI). Diagnosis was further collapsed into cognitive impairment (CI: MCI or dementia) vs no cognitive impairment (NCI). After matching, loadings on the first principal component were higher in the CI vs NCI group in both ADNI (53.1% versus 38.3%) and MemClin (33.3% vs 30.8%). Correlations of all paired combinations of individual tests by diagnostic group were also stronger in the CI group in both ADNI (mean inter-test r = 0.51 vs r = 0.33, p < 0.001) and MemClin (r = 0.31 vs r = 0.27, p = 0.042). Dedifferentiation was explained by cognitive impairment when controlling for age, sex, and education. This finding replicated across two separate, large cohorts of older individuals. Knowledge that the structure of human cognition becomes less diversified and more dependent on general intelligence as a function of cognitive impairment should inform clinical assessment and care for these patients as their neurodegeneration progresses. Impact Journals 2021-05-26 /pmc/articles/PMC8202862/ /pubmed/34038387 http://dx.doi.org/10.18632/aging.203108 Text en Copyright: © 2021 Wallert et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wallert, John
Rennie, Anna
Ferreira, Daniel
Muehlboeck, J-Sebastian
Wahlund, Lars-Olof
Westman, Eric
Ekman, Urban
Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
title Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
title_full Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
title_fullStr Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
title_full_unstemmed Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
title_short Cognitive dedifferentiation as a function of cognitive impairment in the ADNI and MemClin cohorts
title_sort cognitive dedifferentiation as a function of cognitive impairment in the adni and memclin cohorts
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8202862/
https://www.ncbi.nlm.nih.gov/pubmed/34038387
http://dx.doi.org/10.18632/aging.203108
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