Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives

Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream...

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Detalles Bibliográficos
Autores principales: Yong, Jiaxin, Li, Yuan, Lin, Sihan, Wang, Zhenning, Xu, Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove 2021
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203099/
https://www.ncbi.nlm.nih.gov/pubmed/34140763
http://dx.doi.org/10.2147/DDDT.S308377
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author Yong, Jiaxin
Li, Yuan
Lin, Sihan
Wang, Zhenning
Xu, Yan
author_facet Yong, Jiaxin
Li, Yuan
Lin, Sihan
Wang, Zhenning
Xu, Yan
author_sort Yong, Jiaxin
collection PubMed
description Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream effector of the Hippo signaling pathway and a crucial co-transcription factor in the nucleus, is a promising and vital potential drug target for the treatment of GC. A series of drugs or compounds that inhibit YAP has been developed or confirmed. Therefore, this review will focus on summarizing the drugs and small-molecule inhibitors that have been reported to inhibit YAP and discuss the clinical prospects of YAP inhibitors in GC.
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spelling pubmed-82030992021-06-16 Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives Yong, Jiaxin Li, Yuan Lin, Sihan Wang, Zhenning Xu, Yan Drug Des Devel Ther Review Gastric cancer (GC) is one of the most common cancers globally, threatening global health. The deregulation of the Hippo signaling pathway has been discovered in GC and may be related to cancer development, proliferation, metastasis, and drug resistance. Yes-associated protein (YAP), as a downstream effector of the Hippo signaling pathway and a crucial co-transcription factor in the nucleus, is a promising and vital potential drug target for the treatment of GC. A series of drugs or compounds that inhibit YAP has been developed or confirmed. Therefore, this review will focus on summarizing the drugs and small-molecule inhibitors that have been reported to inhibit YAP and discuss the clinical prospects of YAP inhibitors in GC. Dove 2021-06-09 /pmc/articles/PMC8203099/ /pubmed/34140763 http://dx.doi.org/10.2147/DDDT.S308377 Text en © 2021 Yong et al. https://creativecommons.org/licenses/by-nc/3.0/This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/ (https://creativecommons.org/licenses/by-nc/3.0/) ). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php).
spellingShingle Review
Yong, Jiaxin
Li, Yuan
Lin, Sihan
Wang, Zhenning
Xu, Yan
Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
title Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
title_full Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
title_fullStr Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
title_full_unstemmed Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
title_short Inhibitors Targeting YAP in Gastric Cancer: Current Status and Future Perspectives
title_sort inhibitors targeting yap in gastric cancer: current status and future perspectives
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8203099/
https://www.ncbi.nlm.nih.gov/pubmed/34140763
http://dx.doi.org/10.2147/DDDT.S308377
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